Dialysis dose and the diagnosis of hypertension in hemodialysis patients.

Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Research Abstract Details 

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Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Abstract Text:

Rajiv Agarwal,Chandan Saha,

OBJECTIVE: To determine whether simultaneous consideration of pre and postdialysis blood pressure (BP) can improve the prediction of interdialytic ambulatory BP in hemodialysis patients, we analyzed BP obtained before and after dialysis using routine or standardized methods and by self-measurement at home in 104 hemodialysis patients. Evidence for effect modification was tested for several plausible demographic, clinical and laboratory factors. RESULTS: Postdialysis BP when considered jointly with predialysis BP improved the diagnostic performance of standardized dialysis unit BP measurements [receiver operating characteristic (ROC) area under the curve (AUC) 0.91 for joint, 0.85 for prehemodialysis ROC (P=0.01 for difference in AUC)]. A trend to improvement existed in ROC AUC with routine dialysis unit BP measurement [ROC AUC 0.88 for joint, 0.82 for prehemodialysis ROC (P=0.055 for difference in AUC)]. Dialysis dose measured by urea reduction ratio was a strong effect modifier for the determination of hypertension by routine (P=0.012) and standardized (P=0.002) dialysis unit BP measurements. This effect modification was not seen with home BP (P=0.26). CONCLUSION: Simultaneous consideration of predialysis and postdialysis BPs obtained over 2 weeks can improve the diagnosis of hypertension in hemodialysis patients. Dialysis dose may significantly influence the diagnosis of hypertension when dialysis unit BPs are used.

Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Publishing Authors By Initials

R Agarwal,C Saha,

For similar investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: sensitivity and specificity research

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Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Blood pressure monitoring

VOLUME: 12

Page Numbers: 281-7

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ISSN: 1359-5237

DAY: 3

MONTH: Oct

YEAR: 2007

Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Information

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LANGUAGE: eng

NlmUniqueID: 9606438

Dialysis dose and the diagnosis of hypertension in hemodialysis patients. Keywords Mesh Terms:

KEYWORDS: Sensitivity and Specificity

MESH TERMS: methods

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Grant and Affiliation Information for Dialysis dose and the diagnosis of hypertension in hemodialysis patients.

AFFILIATION: Division of Nephrology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA. ragarwal@iupui.edu

Country: England

AGENCY: United States PHS

GRANT: 5R01-062030-04

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MEDLINETA: Blood Press Monit

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