Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies.

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Abstract Text:

Eva ,Josef ,Ladislav Dusek,Klaus V Toyka,Claudia Sommer,Eva ,Josef ,Ladislav Dusek,Klaus V Toyka,Claudia Sommer,

In this prospective study, intraepidermal nerve fiber densities (IENFD) and subepidermal nerve plexus densities (SENPD) were quantified by immunostaining in skin punch biopsies from the distal calf in 99 patients with clinical symptoms of painful sensory neuropathy and from 37 age-matched healthy volunteers. The clinical diagnosis was based on history and abnormal thermal thresholds on quantitative sensory testing (QST). In patients with neuropathy, IENFD and SENPD were reduced to about 50% of controls. Elevated warm detection thresholds on QST correlated with IENFD but not with SENPD. Using receiver-operating characteristic (ROC) curve analysis of IENFD values, the diagnostic sensitivity for detecting neuropathy was 0.80 and the specificity 0.82. For SENPD, sensitivity was 0.81 and specificity 0.88. With ROC analysis of both IENFD and SENPD together, the diagnostic sensitivity was further improved to 0.92. The combined examination of IENFD and SENPD is a highly sensitive and specific diagnostic tool in patients suspected to suffer from painful sensory neuropathies but with normal values on clinical neurophysiological studies. Muscle Nerve, 2007.

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Publishing Authors By Initials

E ,J ,L Dusek,KV Toyka,C Sommer,E ,J ,L Dusek,KV Toyka,C Sommer,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Muscle & nerve

VOLUME: 37

Page Numbers: 50-60

Journal Abbreviation: Muscle Nerve

ISSN: 0148-639X

DAY: 24

MONTH: Jan

YEAR: 2008

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7803146

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies.

AFFILIATION: Department of Neurology, University Hospital Brno, Jihlavska 20, 62500 Brno, Czech Republic.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Muscle Nerve

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies Related Publications

• A large-scale validation of dosage analysis by robust dosage-polymerase chain reaction.
• A mouse model for nonsense mutation bypass therapy shows a dramatic multiday response to geneticin.
• A novel image formation method for ultrasonic strain imaging.
• Analysis of urinary calculi using an infrared microspectroscopic surface reflectance imaging technique.
• Anticytokine therapy in neuropathic pain management.
• Antiinfectives and low-level light: a new chapter in photomedicine.
• Autonomic neurogenesis and apoptosis are alternative fates of progenitor cell communities induced by TGFbeta.
• Candidate gene analyses by scanning or brute force fluorescent sequencing: a comparison of DOVAM-S with gel-based and capillary-based sequencing.
• Classification and management of tracheoesophageal and tracheopharyngeal fistulas after laryngectomy.
• Detection of ultrarare somatic mutation in the human TP53 gene by bidirectional pyrophosphorolysis-activated polymerization allele-specific amplification.
• Diagnostic validity of epidermal nerve fiber densities in painful sensory neuropathies.
• Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice.
• Evidence for mutation showers.
• Evolution of development in nematodes related to C. elegans.
• FDG-PET and FDG-PET/CT in breast cancer.
• Facial attractiveness modulates early and late event-related brain potentials.
• Functional polymorphisms of the 5-HT1A and 5-HT1B receptor are associated with clinical symptoms in migraineurs.
• High-resolution myocardial perfusion imaging at 3 T: comparison to 1.5 T in healthy volunteers.
• In vitro comparison of human fibroblasts from intact and ruptured ACL for use in tissue engineering.
• Magnetic resonance-guided high-intensity ultrasound ablation of the prostate.
• Mean-field treatment of polymer chains trapped between surfaces and penetrable interfaces.
• Molecular Structure and Theoretical Studies of (PPh(4))(2)[Bi(10)Cu(10)(SPh)(24)].
• Pristionchus pacificus.
• Random copolymers at a selective interface: Saturation effects.
• The ClpPX protease is required for radioresistance and regulates cell division after gamma-irradiation in Deinococcus radiodurans.
• The Nematode Pristionchus pacificus (Nematoda: Diplogastridae) Is Associated with the Oriental Beetle Exomala orientalis (Coleoptera: Scarabaeidae) in Japan.
• Toward a fluorescent single-strand conformation polymorphism technique that detects all mutations: F-DOVAM-S.
• Treatment of lymphangioma circumscriptum with the intense pulsed light system.
• [Physical training in the treatment of depressive disorders]
• [Stem cells of the enteric nervous system: causal therapy for Hirschsprung's disease?]