Diagnostic potential for urinary proteomics.

Diagnostic potential for urinary proteomics. Research Abstract Details 

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Diagnostic potential for urinary proteomics. Abstract Text:

Glen L Hortin,Denis Sviridov,

Urine represents a modified ultrafiltrate of plasma, with protein concentrations typically approximately 1000-fold lower than plasma. Urine's low protein concentration might suggest it to be a less promising diagnostic specimen than plasma. However, urine can be obtained noninvasively and tests of many urinary proteins are well-established in clinical practice. Proteomic technologies expand opportunities to analyze urinary proteins, identifying more than 1000 proteins and peptides in urine. Urine offers a sampling of most plasma proteins, with increased proportions of low-molecular-weight protein and peptide components. Urine also offers enriched sampling of proteins released along the urinary tract. Although urine presents some challenges as a diagnostic specimen, its diverse range of potential markers offers great potential for diagnosis of both systemic and kidney diseases. Examples of clinical situations where this may be of value are for more sensitive detection of kidney transplant rejection or of renal toxicity of medications.

Diagnostic potential for urinary proteomics. Publishing Authors By Initials

GL Hortin,D Sviridov,

For similar male urogenital diseases: urologic diseases research abstracts see: male urogenital diseases: urologic diseases research

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Diagnostic potential for urinary proteomics. Journal Published:

PUBLICATION TYPE: Review

Journal: Pharmacogenomics

VOLUME: 8

Page Numbers: 237-55

Journal Abbreviation: Pharmacogenomics

ISSN: 1744-8042

DAY: 3

MONTH: Mar

YEAR: 2007

Diagnostic potential for urinary proteomics. Information

Number of References: 169

LANGUAGE: eng

NlmUniqueID: 100897350

Diagnostic potential for urinary proteomics. Keywords Mesh Terms:

KEYWORDS: Urologic Diseases

MESH TERMS: urine

Chemical & Substance for Abstract: Diagnostic potential for urinary proteomics. Information

Substance Name: Biological Markers

Registry Number: 0

Grant and Affiliation Information for Diagnostic potential for urinary proteomics.

AFFILIATION: National Institutes of Health, Department of Laboratory Medicine, Warren Magnuson Clinical Center, Building 10, Room 2C-407, Bethesda, MD 20892-1508, USA. ghortin@mail.cc.nih.gov

Country: England

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MEDLINETA: Pharmacogenomics

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