Diagnostic markers for early detection of ovarian cancer.

Diagnostic markers for early detection of ovarian cancer. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Diagnostic markers for early detection of ovarian cancer. Abstract Text:

Irene Visintin,Ziding Feng,Gary Longton,David C Ward,Ayesha B Alvero,Yinglei Lai,Jeannette Tenthorey,Aliza Leiser,Ruben Flores-Saaib,Herbert Yu,Masoud Azori,Thomas Rutherford,Peter E Schwartz,Gil Mor,

PURPOSE: Early detection would significantly decrease the mortality rate of ovarian cancer. In this study, we characterize and validate the combination of six serum biomarkers that discriminate between disease-free and ovarian cancer patients with high efficiency. EXPERIMENTAL DESIGN: We analyzed 362 healthy controls and 156 newly diagnosed ovarian cancer patients. Concentrations of leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, and CA-125 were determined using a multiplex, bead-based, immunoassay system. All six markers were evaluated in a training set (181 samples from the control group and 113 samples from OC patients) and a test set (181 sample control group and 43 ovarian cancer). RESULTS: Multiplex and ELISA exhibited the same pattern of expression for all the biomarkers. None of the biomarkers by themselves were good enough to differentiate healthy versus cancer cells. However, the combination of the six markers provided a better differentiation than CA-125. Four models with <2% classification error in training sets all had significant improvement (sensitivity 84%-98% at specificity 95%) over CA-125 (sensitivity 72% at specificity 95%) in the test set. The chosen model correctly classified 221 out of 224 specimens in the test set, with a classification accuracy of 98.7%. CONCLUSIONS: We describe the first blood biomarker test with a sensitivity of 95.3% and a specificity of 99.4% for the detection of ovarian cancer. Six markers provided a significant improvement over CA-125 alone for ovarian cancer detection. Validation was performed with a blinded cohort. This novel multiplex platform has the potential for efficient screening in patients who are at high risk for ovarian cancer.

Diagnostic markers for early detection of ovarian cancer. Publishing Authors By Initials

I Visintin,Z Feng,G Longton,DC Ward,AB Alvero,Y Lai,J Tenthorey,A Leiser,R Flores-Saaib,H Yu,M Azori,T Rutherford,PE Schwartz,G Mor,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Diagnostic markers for early detection of ovarian cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical cancer research : an official journal of

VOLUME: 14

Page Numbers: 1065-72

Journal Abbreviation: Clin. Cancer Res.

ISSN: 1078-0432

DAY: 7

MONTH: 02

YEAR: 2008

Diagnostic markers for early detection of ovarian cancer. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9502500

Diagnostic markers for early detection of ovarian cancer. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Diagnostic markers for early detection of ovarian cancer. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Diagnostic markers for early detection of ovarian cancer.

AFFILIATION: Authors' Affiliations: Departments of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Clin Cancer Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Diagnostic markers for early detection of ovarian cancer Related Publications

• Balancing regulatory controls and incentives: toward smarter and more transparent oversight in long-term care.
• Cancers take their Toll--the function and regulation of Toll-like receptors in cancer cells.
• Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines.
• Decisions to forgo hospitalization in advanced dementia: a nationwide study.
• Defining and measuring quality outcomes in long-term care.
• Defining and measuring quality outcomes in long-term care.
• Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection.
• Diagnostic markers for early detection of ovarian cancer.
• Dysfunctional implications of narrow window theory: variability in the intuitive assessment of correlation.
• Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C).
• First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis.
• Government expenditures at the end of life for short- and long-stay nursing home residents: differences by hospice enrollment status.
• Hospice Effect on Government Expenditures among Nursing Home Residents.
• Hospitalization of nursing home residents with cognitive impairments: the influence of organizational features and state policies.
• Hospitalization of nursing home residents: the effects of states' Medicaid payment and bed-hold policies.
• In vitro discriminative antipseudomonal properties resulting from acyl substitution of N-terminal sequence of dermaseptin s4 derivatives.
• Is dementia special care really special? A new look at an old question.
• Long-term care market competition and nursing home dementia special care units.
• Medicaid payment rates, case-mix reimbursement, and nursing home staffing--1996-2004.
• MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer.
• Pediatric transperitoneal laparoscopic partial nephrectomy: comparison with an age-matched group undergoing open surgery.
• Phenoxodiol-Topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects.
• Plant-derived human acetylcholinesterase-R provides protection from lethal organophosphate poisoning and its chronic aftermath.
• Quantum key distribution with classical Bob.
• Studies on denitrification. VII. Further purification and properties of denitrifying enzyme.
• Synthesis and stability in biological media of 1H-imidazole-1-carboxylates of ROS203, an antagonist of the histamine H3 receptor.
• Translational control of recombinant human acetylcholinesterase accumulation in plants.
• Trophoblast-macrophage interactions: a regulatory network for the protection of pregnancy.
• X-linked inhibitor of apoptosis (XIAP) confers human trophoblast cell resistance to Fas-mediated apoptosis.
• [Not Available.]