Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging.

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Research Abstract Details 

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Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Abstract Text:

J A Jo,Q Fang,T Papaioannou,J H Qiao,M C Fishbein,B Beseth,A H Dorafshar,T Reil,D Baker,J Freischlag,K K Shung,L Sun,L Marcu,J A Jo,Q Fang,T Papaioannou,J H Qiao,M C Fishbein,B Beseth,A H Dorafshar,T Reil,D Baker,J Freischlag,K K Shung,L Sun,L Marcu,

In this study, time-resolved laser-induced fluorescence spectroscopy (TR-LIFS) and ultrasonography were applied to detect vulnerable (high-risk) atherosclerotic plaque. A total of 813 TR-LIFS measurements were taken from carotid plaques of 65 patients, and subsequently analyzed using the Laguerre deconvolution technique. The investigated spots were classified by histopathology as thin, fibrotic, calcified, low-inflamed, inflamed and necrotic lesions. Spectral and time-resolved parameters (normalized intensity values and Laguerre expansion coefficients) were extracted from the TR-LIFS data. Feature selection for classification was performed by either analysis of variance (ANOVA) or principal component analysis (PCA). A stepwise linear discriminant analysis algorithm was developed for detecting inflamed and necrotic lesion, representing the most vulnerable plaques. These vulnerable plaques were detected with high sensitivity (>80%) and specificity (>90%). Ultrasound (US) imaging was obtained in 4 carotid plaques in addition to TR-LIFS examination. Preliminary results indicate that US provides important structural information of the plaques that could be combined with the compositional information obtained by TR-LIFS, to obtain a more accurate diagnosis of vulnerable atherosclerotic plaque.

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Publishing Authors By Initials

JA Jo,Q Fang,T Papaioannou,JH Qiao,MC Fishbein,B Beseth,AH Dorafshar,T Reil,D Baker,J Freischlag,KK Shung,L Sun,L Marcu,JA Jo,Q Fang,T Papaioannou,JH Qiao,MC Fishbein,B Beseth,AH Dorafshar,T Reil,D Baker,J Freischlag,KK Shung,L Sun,L Marcu,

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Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Conference proceedings : ... Annual International

VOLUME: 1

Page Numbers: 2663-6

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ISSN: 1557-170X

DAY: 23

MONTH: 10

YEAR: 2006

Diagnosis of vulnerable atherosclerotic plaques by time-resolved fluorescence spectroscopy and ultrasound imaging. Information

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LANGUAGE: eng

NlmUniqueID: 101243413

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AFFILIATION: Dept. of Biomed. Eng., California Davis Univ., CA.

Country: United States

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MEDLINETA: Conf Proc IEEE Eng Med Biol So

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