Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography.

Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Research Abstract Details 

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Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Abstract Text:

R O Bude,R S Adler,D R Bassett,

OBJECTIVE. The purpose of this study was twofold: (1) to determine the characteristic MR appearance of the xanthomatous tendons of heterozygous familial hypercholesterolemia and (2) to determine which of two imaging techniques, high-frequency linear-array sonography or MR imaging, is better for detection of xanthomas. SUBJECTS AND METHODS. Sonography and MR imaging were performed to evaluate the Achilles tendons in 10 patients (20 tendons) with heterozygous familial hypercholesterolemia. For sonography, 7.5- (nine patients) and 10.0- (one patient) MHz transducers were used. T1-weighted, proton density-weighted, and T2-weighted MR images were obtained at 0.5 T (four patients) and 1.5 T (six patients), including fat-suppressed (six patients) and water-suppressed (one patient) T1-weighted images at 1.5 T. Tendon abnormalities detected with both techniques were noted, and the results were compared. RESULTS. In all tendons, sonograms showed focal hypoechoic lesions compatible with xanthomas. MR images did not show focal lesions. Instead, all pulse sequences showed a diffuse speckled or reticulated pattern or both on axial images. This speckled or reticulated appearance was more obvious on fat-suppressed T1-weighted images and much less evident on water-suppressed T1-weighted images. Contrast resolution was subjectively better on sonograms than on MR images in all cases. CONCLUSION. The speckled or reticulated appearance is a characteristic, if not pathognomonic, MR feature of xanthomatous tendons and probably is due to edema or inflammation, not intratendinous lipid. However, localized lipid deposits detected on sonograms are more readily quantified than are the lesions seen on MR images. Therefore, we think sonography, rather than MR imaging as performed in our study, is the technique of choice for detecting xanthomas.

Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Publishing Authors By Initials

RO Bude,RS Adler,DR Bassett,

For similar nutritional and metabolic diseases: metabolic diseases: lipid metabolism disorders: xanthomatosis research abstracts see: nutritional and metabolic diseases: metabolic diseases: lipid metabolism disorders: xanthomatosis research

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Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 162

Page Numbers: 913-7

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: Apr

YEAR: 1994

Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography. Keywords Mesh Terms:

KEYWORDS: Xanthomatosis

MESH TERMS: ultrasonography

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Grant and Affiliation Information for Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography.

AFFILIATION: Department of Radiology, University of Michigan Medical School, Taubman Center, Ann Arbor 48109.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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