Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta).

Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta). Research Abstract Details 

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Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta). Abstract Text:

Cora L Singleton,Raymund F Wack,Tanja S Zabka,Michael S Kent,R Scott Larsen,

Physical examination of an asymptomatic 20-yr-old intact female spotted hyena (Crocuta crocuta) revealed a midabdominal mass. A complete blood count (CBC) revealed peripheral lymphocytosis. Abdominal ultrasonography and laparoscopy confirmed severe splenomegaly. Cytologic examination of a bone-marrow core and histologic examination of spleen and liver biopsy samples revealed neoplastic small lymphocytes. Immunohistochemical staining of liver and spleen samples with the use of leukocyte-specific monoclonal antibodies showed that the neoplastic lymphocytes were immunoreactive to T-lymphocyte CD3 receptor and immunonegative to B-lymphocyte CD79a receptor. The morphology and distribution of neoplastic T-lymphocytes within the spleen, liver, peripheral blood, and bone marrow was most consistent with chronic T-lymphocytic leukemia. Treatment with chlorambucil and prednisone effectively decreased the lymphocyte count, but was associated with thrombocytopenia, which resolved after chlorambucil treatment was temporarily discontinued. Chemotherapy was resumed with a single dose of L-asparaginase, followed by a lower dosage of chlorambucil and continued prednisone. Two years after initial diagnosis, the hyena developed a hemoabdomen and was euthanized. Neoplastic T-lymphocytes were present in spleen, liver, visceral and peripheral lymph nodes, lungs, heart, kidney, adrenal glands, mesentery, intestines, pancreas, brain, and bone marrow.

Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta). Publishing Authors By Initials

CL Singleton,RF Wack,TS Zabka,MS Kent,RS Larsen,

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Diagnosis and treatment of chronic T-lymphocytic leukemia in a spotted hyena (Crocuta crocuta). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of zoo and wildlife medicine : official pu

VOLUME: 38

Page Numbers: 488-91

Journal Abbreviation: J. Zoo Wildl. Med.

ISSN: 1042-7260

DAY: 3

MONTH: Sep

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: Zoological Medicine Service, School of Veterinary Medicine, University of California, Davis, California 95616, USA. cora.singleton@lacity.org

Country: United States

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MEDLINETA: J Zoo Wildl Med

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