Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Research Abstract Details 

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Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Abstract Text:

OBJECTIVES: To assess the accuracy of 18F-fluoro-L-dihydroxyphenylalanine ([18F]-DOPA) PET scans to diagnose focal versus diffuse disease and to localize focal lesions in infants with congenital hyperinsulinism. STUDY DESIGN: Twenty-four infants with hyperinsulinism unresponsive to medical therapy were studied. Patients were injected intravenously with [18F]-DOPA, and PET scans were obtained for 1 hour. Images were coregistered with abdominal CT scans. RESULTS: The diagnosis of focal or diffuse hyperinsulinism was correct in 23 of the 24 cases (96%) and equivocal in 1 case. [18F]-DOPA PET identified focal areas of high uptake of radiopharmaceutical in 11 patients. Pathology results confirmed that all 11 had focal adenomatosis, and the locations of these lesions matched the areas of increased [18F]-DOPA uptake on the PET scans in all of the cases. CONCLUSIONS: [18F]-DOPA PET scans were 96% accurate in diagnosing focal or diffuse disease and 100% accurate in localizing the focal lesion. These results suggest that [18F]-DOPA PET imaging should be considered in all infants with congenital hyperinsulinism who need to have pancreatectomy.

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research abstracts see: investigative techniques: epidemiologic methods: data collection: health surveys: health status indicators: severity of illness index research

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Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of pediatrics

VOLUME: 150

Page Numbers: 140-5

Journal Abbreviation: J. Pediatr.

ISSN: 1097-6833

DAY: 3

MONTH: Feb

YEAR: 2007

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375410

Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Keywords Mesh Terms:

KEYWORDS: Severity of Illness Index

MESH TERMS: methods

Chemical & Substance for Abstract: Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan. Information

Substance Name: fluorodopa F 18

Registry Number: 75290-51-6

Grant and Affiliation Information for Diagnosis and localization of focal congenital hyperinsulinism by 18F-fluorodopa PET scan.

AFFILIATION: Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: T32-DK63688

ACRONYM: DK

MEDLINETA: J Pediatr

REFSOURCE: J Pediatr. 2007 Feb;150(2):122-4

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