Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Research Abstract Details 

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Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Abstract Text:

Kristen L King,Martin E Young,Janos Kerner,Hazel Huang,Karen M O'Shea,Stefan E H Alexson,Charles L Hoppel,William C Stanley,

Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a transcriptional regulator of the expression of mitochondrial thioesterase I (MTE-I) and uncoupling protein 3 (UCP3), which are induced in the heart at the mRNA level in response to diabetes. Little is known about the regulation of protein expression of MTE-I and UCP3 or about MTE-I activity; thus, we investigated the effects of diabetes and treatment with a PPAR alpha agonist on these parameters. Rats were either made diabetic with streptozotocin (55 mg/kg ip) and maintained for 10-14 days or treated with the PPAR alpha agonist fenofibrate (300 mg/kg/day) for 4 weeks. MTE-I and UCP3 protein expression, MTE-1 activity, palmitate export, and oxidative phosphorylation were measured in isolated cardiac mitochondria. Diabetes and fenofibrate increased cardiac MTE-I mRNA, protein, and activity ( approximately 4-fold compared with controls). This increase in activity was matched by a 6-fold increase in palmitate export in fenofibrate-treated animals, despite there being no effect in either group on UCP3 protein expression. Both diabetes and fenofibrate caused significant decreases in state III respiration of isolated mitochondria with pyruvate + malate as the substrate, but only diabetes reduced state III rates with palmitoylcarnitine. Both diabetes and specific PPAR alpha activation increased MTE-I protein, activity, and palmitate export in the heart, with little effect on UCP3 protein expression.

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Publishing Authors By Initials

KL King,ME Young,J Kerner,H Huang,KM O'Shea,SE Alexson,CL Hoppel,WC Stanley,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, wistar research

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Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of lipid research

VOLUME: 48

Page Numbers: 1511-7

Journal Abbreviation: J. Lipid Res.

ISSN: 0022-2275

DAY: 16

MONTH: 04

YEAR: 2007

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376606

Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Keywords Mesh Terms:

KEYWORDS: Rats, Wistar

MESH TERMS: metabolism

Chemical & Substance for Abstract: Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart. Information

Substance Name: Palmitoyl-CoA Hydrolase

Registry Number: EC 3.1.2.2

Grant and Affiliation Information for Diabetes or peroxisome proliferator-activated receptor alpha agonist increases mitochondrial thioesterase I activity in heart.

AFFILIATION: Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL074259

ACRONYM: HL

MEDLINETA: J Lipid Res

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