Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study.

Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Research Abstract Details 

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Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Abstract Text:

John C Lieske, de la Vega,Matthew T Gettman,Jeffrey M Slezak,Eric J Bergstralh,L Joseph Melton,Cynthia L Leibson,

BACKGROUND: Because nephrolithiasis has been associated with obesity, an important risk factor for type 2 diabetes mellitus (DM), we tested the hypothesis that DM prevalence is increased in individuals who develop renal stones. METHODS: In an initial electronic analysis, prior diagnoses of DM, hypertension, and obesity were compared between all Olmsted County, MN, residents with a diagnosis code for nephrolithiasis between 1980 and 1999 and matched residents of similar age and sex (N = 3,561 case-control pairs). A random sample of 260 cases and corresponding controls was selected for detailed medical record review to confirm and characterize the stone event and obtain heights, weights, blood pressures, and glucose and cholesterol values. RESULTS: In the electronic analysis, unadjusted odds ratios (ORs) for DM (OR, 1.29; 95% confidence interval [CI], 1.09 to 1.53), obesity (OR, 1.15; 95% CI, 1.02 to 1.31), and hypertension (OR, 1.19; 95% CI, 1.04 to 1.35) were increased significantly for nephrolithiasis cases versus controls; DM remained significant after adjustment for age, sex, calendar year, hypertension, and obesity (OR, 1.22; 95% CI, 1.03 to 1.46). Detailed record review of a subset showed significant increases for cases versus controls for body mass index (OR, 1.05; 95% CI, 1.01 to -1.09) and hypertension (OR, 1.71; 95% CI, 1.17 to 2.59). Odds for DM were increased, but not significantly, in the subsample (OR, 1.44; 95% CI, 0.76 to 2.72). Among cases with stone analyses, those with uric acid stones (n = 10) had a greater percentage of DM compared with those with all other stone types (n = 112; 40% versus 9%; P = 0.02). CONCLUSION: Findings from this population-based study suggest that DM, obesity, and hypertension are associated with nephrolithiasis, and DM may be a factor in the development of uric acid stones.

Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Publishing Authors By Initials

JC Lieske,LS de la Vega,MT Gettman,JM Slezak,EJ Bergstralh,LJ Melton,CL Leibson,

For similar investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research abstracts see: investigative techniques: epidemiologic methods: data collection: vital statistics: morbidity: prevalence research

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Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of kidney diseases : the official

VOLUME: 48

Page Numbers: 897-904

Journal Abbreviation: Am. J. Kidney Dis.

ISSN: 1523-6838

DAY: 3

MONTH: Dec

YEAR: 2006

Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Information

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LANGUAGE: eng

NlmUniqueID: 8110075

Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study. Keywords Mesh Terms:

KEYWORDS: Prevalence

MESH TERMS: epidemiology

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Grant and Affiliation Information for Diabetes mellitus and the risk of urinary tract stones: a population-based case-control study.

AFFILIATION: Department of Internal Medicine, Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. lieske.john@mayo.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK 60707

ACRONYM: DK

MEDLINETA: Am J Kidney Dis

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