Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.

Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Research Abstract Details 

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Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Abstract Text:

Denise M Arrick,Glenda M Sharpe,Hong Sun,William G Mayhan,

Our goal was to identify the role of poly(ADP-ribose) polymerase (PARP) in cerebrovascular dysfunction in Type 1 diabetes mellitus (T1D). In a first series of studies, rats were assigned to nondiabetic and diabetic (streptozotocin; 50 mg/kg IP) groups. Two to three months after injection of streptozotocin, we examine in vivo responses of pial arterioles to nitric oxide synthase (NOS)-dependent (adenosine diphosphate (ADP), acetylcholine and histamine) and -independent (nitroglycerin) agonists. After the initial examination of reactivity to the agonists, we treated pial arterioles acutely with an inhibitor of PARP (PJ-34; 1 microM), and then we again examined responses to the agonists. In a second series of studies, we examine superoxide production (lucigenin chemiluminescence) by parietal cortex tissue in nondiabetic and diabetic rats. We found that dilation of pial arterioles in response to ADP, acetylcholine and histamine, but not to nitroglycerin, was impaired in diabetic compared to nondiabetic rats. In addition, although PJ-34 did not alter responses in nondiabetic rats, PJ-34 alleviated T1D-induced impairment of NOS-dependent vasodilation. We also found that basal production of superoxide was increased in diabetic compared to nondiabetic rats and that PJ-34 decreased this basal production of superoxide. Our findings suggest that T1D impairs NOS-dependent reactivity of cerebral arterioles by a mechanism that appears to be related to the formation of superoxide via activation of PARP.

Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Publishing Authors By Initials

DM Arrick,GM Sharpe,H Sun,WG Mayhan,

For similar vasodilation research abstracts see: vasodilation research

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Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Microvascular research

VOLUME: 73

Page Numbers: 1-6

Journal Abbreviation: Microvasc. Res.

ISSN: 0026-2862

DAY: 18

MONTH: 09

YEAR: 2006

Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 165035

Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Keywords Mesh Terms:

KEYWORDS: Vasodilation

MESH TERMS: drug effects

Chemical & Substance for Abstract: Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase. Information

Substance Name: Poly(ADP-ribose) Polymerases

Registry Number: EC 2.4.2.30

Grant and Affiliation Information for Diabetes-induced cerebrovascular dysfunction: role of poly(ADP-ribose) polymerase.

AFFILIATION: Department of Cellular and Integrative Physiology 985850 Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198-5850, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 79587

ACRONYM: HL

MEDLINETA: Microvasc Res

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