Developmental toxicity evaluation of berberine in rats and mice.

Developmental toxicity evaluation of berberine in rats and mice. Research Abstract Details 

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Developmental toxicity evaluation of berberine in rats and mice. Abstract Text:

Gloria D Jahnke,Catherine J Price,Melissa C Marr,Christina B Myers,Julia D George,

BACKGROUND: Berberine, a plant alkaloid, is found in some herbal teas and health-related products. It is a component of goldenseal, an herbal supplement. Berberine chloride dihydrate (BCD) was evaluated for developmental toxicity in rats and mice. METHODS: Berberine chloride dihydrate was administered in the feed to timed-mated Sprague-Dawley (CD) rats (0, 3,625, 7,250, or 14,500 ppm; on gestational days [GD] 6-20), and Swiss Albino (CD-1) mice (0, 3,500, 5,250, or 7,000 ppm; on GD 6-17). Ingested doses were 0, 282, 531, and 1,313 mg/kg/day (rats) and 0, 569, 841, and 1,155 mg/kg/day (mice). RESULTS: There were no maternal deaths. The rat maternal lowest observed adverse effect level (LOAEL), based on reduced maternal weight gain, was 7,250 ppm. The rat developmental toxicity LOAEL, based on reduced fetal body weight per litter, was 14,500 ppm. In the mouse study, equivocal maternal and developmental toxicity LOAELs were 5,250 ppm. Due to scattering of feed in the high dose groups, a gavage study at 1,000 mg/kg/day was conducted in both species. CONCLUSIONS: In rats, maternal, but not fetal adverse effects were noted. The maternal toxicity LOAEL remained at 7,250 ppm (531 mg/kg/day) based on the feed study and the developmental toxicity NOAEL was raised to 1,000 mg/kg/day BCD based on the gavage study. In the mouse, 33% of the treated females died. Surviving animals had increased relative water intake, and average fetal body weight per litter decreased 5-6% with no change in live litter size. The maternal toxicity LOAEL remained at 5,250 ppm (841 mg/kg/day) BCD, based on increased water consumption. The developmental toxicity LOAEL was raised to 1,000 mg/kg/day BCD based on decreased fetal body weight.

Developmental toxicity evaluation of berberine in rats and mice. Publishing Authors By Initials

GD Jahnke,CJ Price,MC Marr,CB Myers,JD George,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

PUBMED ID PMID:

MEDLINE DATE:

Developmental toxicity evaluation of berberine in rats and mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Birth defects research. Part B, Developmental and

VOLUME: 77

Page Numbers: 195-206

Journal Abbreviation: Birth Defects Res. B Dev. Repr

ISSN: 1542-9733

DAY: 3

MONTH: Jun

YEAR: 2006

Developmental toxicity evaluation of berberine in rats and mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101155115

Developmental toxicity evaluation of berberine in rats and mice. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: embryology

Chemical & Substance for Abstract: Developmental toxicity evaluation of berberine in rats and mice. Information

Substance Name: Berberine

Registry Number: 2086-83-1

Grant and Affiliation Information for Developmental toxicity evaluation of berberine in rats and mice.

AFFILIATION: Sciences International Inc., Research Triangle Park, North Carolina 27709, USA. Janke@niehs.nih.gov

Country: United States

AGENCY: United States NIEHS

GRANT: N01-ES-65405

ACRONYM: ES

MEDLINETA: Birth Defects Res B Dev Reprod

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