Developmental regulation of lumenal lung fluid and electrolyte transport.

Developmental regulation of lumenal lung fluid and electrolyte transport. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Developmental regulation of lumenal lung fluid and electrolyte transport. Abstract Text:

S M Wilson,R E Olver,D V Walters,S M Wilson,R E Olver,D V Walters,S M Wilson,R E Olver,D V Walters,

In the fetus, there is a net secretion of liquid (LL) by the lung as a result of active transport of chloride ions. The rate of secretion and the resulting volume of LL are vital for normal lung growth but how volume is sensed and how secretion may be regulated are still unknown. Towards term under the influence of thyroid and adrenocorticoid hormones, the epithelial sodium channel (ENaC) is increasingly expressed in the pulmonary epithelium. Adrenaline released by the fetus during labour activates ENaC and produces rapid absorption of liquid in preparation for air breathing; absence of ENaC is incompatible with survival. There may be other mechanisms involved in aiding liquid clearance including changes in epithelial permeability, an effect of oxygen on both ENaC and Na/K ATPase and perhaps the influence of additional hormones on ENaC activity. Some time after birth there are further developmental changes with the appearance of other cation channels (CNG1 and perhaps NSCC) which contribute to the liquid absorptive side of the balance existing across the epithelium between secretion and absorption to produce essentially almost no net liquid movement in the postnatal lung. The evidence for these processes is discussed and areas of uncertainty indicated.

Developmental regulation of lumenal lung fluid and electrolyte transport. Publishing Authors By Initials

SM Wilson,RE Olver,DV Walters,SM Wilson,RE Olver,DV Walters,SM Wilson,RE Olver,DV Walters,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Developmental regulation of lumenal lung fluid and electrolyte transport. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Respiratory physiology & neurobiology

VOLUME: 159

Page Numbers: 247-55

Journal Abbreviation:

ISSN: 1569-9048

DAY: 13

MONTH: 10

YEAR: 2007

Developmental regulation of lumenal lung fluid and electrolyte transport. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101140022

Developmental regulation of lumenal lung fluid and electrolyte transport. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Developmental regulation of lumenal lung fluid and electrolyte transport. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Developmental regulation of lumenal lung fluid and electrolyte transport.

AFFILIATION: Lung Membrane Transport Group, Division of Maternal and Child Health Sciences, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, United Kingdom.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Respir Physiol Neurobiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Developmental regulation of lumenal lung fluid and electrolyte transport Related Publications

• Accumulation of topical naproxen by cultured oral epithelium.
• Associations between reduced diffusing capacity and airflow obstruction in community-based subjects.
• Calorimetric properties of water and triacylglycerols in fern spores relating to storage at cryogenic temperatures.
• Characterization of minocycline transport by human neutrophils.
• Clinical predictors of urinary retention after pelvic reconstructive and stress urinary incontinence surgery.
• Coeliac disease often goes undiagnosed.
• Communicating health ... saving lives.
• Defining how ubiquitin receptors hHR23a and S5a bind polyubiquitin.
• Delayed initiation of the pharyngeal swallow: normal variability in adult swallows.
• Developmental regulation of lumenal lung fluid and electrolyte transport.
• Diabetic foot infections in the elderly: primary amputation versus 'foot-sparing surgery'. A case report.
• Diagnosis and outcome measures in trials for neoplastic meningitis: a review of the literature and clinical experience.
• Dopamine lesion-induced changes in subthalamic nucleus activity are not associated with alterations in firing rate or pattern in layer V neurons of the anterior cingulate cortex in anesthetized rats.
• Effect of myeloablative bone marrow transplantation on growth in children with sickle cell anaemia: results of the multicenter study of haematopoietic cell transplantation for sickle cell anaemia.
• Evaluation and management of complete vaginal eversion after retropubic urethropexy.
• External K activation of Kir1.1 depends on the pH gate.
• Family structure, stress, and psychological distress: a demonstration of the impact of differential exposure.
• Myocardial infarction after oral sumatriptan use in a woman with normal coronary arteries.
• NMR-based model reveals the structural determinants of mammalian arylamine N-acetyltransferase substrate specificity.
• Neuronal differentiation and expression of neural epitopes in pituitary adenomas.
• Personal carbon trading: a potential "stealth intervention" for obesity reduction?
• Placenta percreta: A rare cause of uterine rupture during the second trimester of pregnancy.
• Pulse oximetry knowledge and its effects on clinical practice.
• Residual effects of compost and plowing on phosphorus and sediment in runoff.
• Rigorous confidence intervals for critical probabilities.
• Serotonin induces memory-like, rapamycin-sensitive hyperexcitability in sensory axons of aplysia that contributes to injury responses.
• Specificity of machine, barbell, and water-filled log bench press resistance training on measures of strength.
• The SH3 domain of a M7 interacts with its C-terminal proline-rich region.
• Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies.
• Ubiquitin receptor proteins hHR23a and hPLIC2 interact.