Developmental origins of obesity: a sympathoadrenal perspective.

Developmental origins of obesity: a sympathoadrenal perspective. Research Abstract Details 

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Developmental origins of obesity: a sympathoadrenal perspective. Abstract Text:

J B Young,

Environmental exposures at crucial points in development permanently alter sympathoadrenal function in mammals. Both the sympathetic innervation of peripheral tissues and the responsiveness of sympathetic nerves and adrenal medulla to standard stimuli are susceptible to modification by exposures in early life. Several conditions studied in the laboratory, including environmental temperature, litter size and maternal nutrition, in addition to affecting sympathoadrenal function also produce larger, fatter offspring, raising the possibility that developmental programming of the sympathetic nervous system (SNS) may contribute to acquisition of an obese phenotype. The specific changes noted in all three circumstances include evidence of an increase in sympathetic innervation in pancreas and retroperitoneal fat. By contrast, SNS development is impaired in experimental models of intrauterine growth retardation. Although the physiological implications of increased sympathetic innervation in pancreas and retroperitoneal fat are not fully understood, these changes seen in animals reared at cool temperatures, in small litters or by mothers fed refined carbohydrate diets likely reflect an early enhancement of the offspring's capacity to take up and store glucose. If so, the tendency of these animals to gain weight and accumulate fat may represent an adaptive response to 'over-nutrition' in early life.

Developmental origins of obesity: a sympathoadrenal perspective. Publishing Authors By Initials

JB Young,

For similar environment and public health: environment: environment, controlled: temperature research abstracts see: environment and public health: environment: environment, controlled: temperature research

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Developmental origins of obesity: a sympathoadrenal perspective. Journal Published:

PUBLICATION TYPE: Review

Journal: International journal of obesity (2005)

VOLUME: 30 Suppl 4

Page Numbers: S41-9

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ISSN: 0307-0565

DAY: 3

MONTH: Dec

YEAR: 2006

Developmental origins of obesity: a sympathoadrenal perspective. Information

Number of References: 112

LANGUAGE: eng

NlmUniqueID: 101256108

Developmental origins of obesity: a sympathoadrenal perspective. Keywords Mesh Terms:

KEYWORDS: Temperature

MESH TERMS: growth & development

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Grant and Affiliation Information for Developmental origins of obesity: a sympathoadrenal perspective.

AFFILIATION: Department of Medicine, The Feinberg School of Medicine of Northwestern University, Chicago, IL 60611, USA. jbyoung@northwestern.edu

Country: England

AGENCY: United States NIDDK

GRANT: DK 20378

ACRONYM: DK

MEDLINETA: Int J Obes (Lond)

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