Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord.

Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. Research Abstract Details 

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Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. Abstract Text:

Ursula Greferath,Alison J Canty,Jonathan Messenger,Mark Murphy,

Eph receptor tyrosine kinases and their ephrin ligands are involved in some of the most important steps during the development of the central nervous system, including cell migration, axon guidance, topographic mapping and synapse formation. Moreover, in the adult, they have been implicated in plasticity and regulation of neural stem cell function. One member of the Eph family, EphA4, can bind to both classes of ephrins and may have multiple functions in nervous system development. In order to look for potential sites of EphA4 action during central nervous system development, we conducted a spatio-temporal analysis of EphA4 protein expression. We used immunohistochemistry in preference to in situ hybridization because of the high likelihood that EphA4 protein is expressed on axon tracts, long distances from EphA4 mRNA. In the telencephalon, EphA4 was expressed in the developing cortex from embryonic day 11 (E11) and, later, on major cortical tracts including the corpus callosum and cortico-spinal tract. Robust EphA4 expression was also found in the hippocampus and fornix, and cells and tracts in the striatum. In the diencephalon, the thalamus, the hypothalamus and thalamo-cortical projection were strongly positive. In the mesencephalon, a number of different nuclei were weakly positive, most prominently the red nucleus. In the rhombencephalon, many nuclei were strongly positive including the cerebellum and one of its afferent paths, the inferior cerebellar peduncle, as well as the olivary region. In the spinal cord, there was a dynamic pattern of expression through development, with persistent expression in the dorsal funiculus and ventral grey matter.

Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. Publishing Authors By Initials

U Greferath,AJ Canty,J Messenger,M Murphy,

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Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Mechanisms of development

VOLUME: 119 Suppl 1

Page Numbers: S231-8

Journal Abbreviation: Mech. Dev.

ISSN: 0925-4773

DAY: 30

MONTH: Dec

YEAR: 2002

Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord.

AFFILIATION: Department of Anatomy and Cell Biology, University of Melbourne, Victoria 3010, Australia. ursulag@unimelb.edu.au

Country: Ireland

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MEDLINETA: Mech Dev

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