Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function.

Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Research Abstract Details 

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Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Abstract Text:

Mehmet Uzumcu,Rob Zachow,

Female reproductive function depends upon the exquisite control of ovarian steroidogenesis that enables folliculogenesis, ovulation, and pregnancy. These mechanisms are set during fetal and/or neonatal development and undergo phases of differentiation throughout pre- and post-pubescent life. Ovarian development and function are collectively regulated by a host of endogenous growth factors, cytokines, gonadotropins, and steroid hormones as well as exogenous factors such as nutrients and environmental agents. Endocrine disruptors represent one class of environmental agent that can impact female fertility by altering ovarian development and function, purportedly through estrogenic, anti-estrogenic, and/or anti-androgenic effects. This review discusses ovarian development and function and how these processes are affected by some of the known estrogenic and anti-androgenic endocrine disruptors. Recent information suggests not only that exposure to endocrine disruptors during the developmental period causes reproductive abnormalities in adult life but also that these abnormalities are transgenerational. This latter finding adds another level of importance for identifying and understanding the mechanisms of action of these agents.

Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Publishing Authors By Initials

M Uzumcu,R Zachow,

For similar reproductive and urinary physiology: reproduction research abstracts see: reproductive and urinary physiology: reproduction research

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Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Journal Published:

PUBLICATION TYPE: Review

Journal: Reproductive toxicology (Elmsford, N.Y.)

VOLUME: 23

Page Numbers: 337-52

Journal Abbreviation:

ISSN: 0890-6238

DAY: 6

MONTH: 11

YEAR: 2006

Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Information

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LANGUAGE: eng

NlmUniqueID: 8803591

Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Keywords Mesh Terms:

KEYWORDS: Reproduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function. Information

Substance Name: Environmental Pollutants

Registry Number: 0

Grant and Affiliation Information for Developmental exposure to environmental endocrine disruptors: consequences within the ovary and on female reproductive function.

AFFILIATION: Department of Animal Sciences, School of Environmental and Biological Sciences, Rutgers, The State University of New Jersey, 84 Lipman Drive, New Brunswick, NJ 08901-8525, United States. uzumcu@aesop.rutgers.edu

Country: United States

AGENCY: United States NIEHS

GRANT: R21 ES013854-01A1

ACRONYM: ES

MEDLINETA: Reprod Toxicol

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