Developmental changes of cerebral blood flow and oxygen metabolism in children.

Developmental changes of cerebral blood flow and oxygen metabolism in children. Research Abstract Details 

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Developmental changes of cerebral blood flow and oxygen metabolism in children. Abstract Text:

T Takahashi,R Shirane,S Sato,T Yoshimoto,

BACKGROUND AND PURPOSE: Normal values for cerebral blood flow (CBF) and metabolism in adults are well established, but not for children. Our goal, therefore, was to clarify functional developmental changes of the brain in children in relation to CBF and oxygen metabolism. METHODS: We measured regional CBF (rCBF), regional cerebral metabolic rate for oxygen (rCMRO2), and regional oxygen extraction fraction (rOEF), using positron emission tomography (PET). We performed 30 PET studies in 24 children ages 10 days to 16 years (nine boys, 15 girls), using a steady inhalation method with C(15)O2, (15)O2, and 15CO in order to measure rCBF, rCMRO2, and rOEF, respectively. Regions of interest were set in the primary cerebral areas (sensorimotor, visual, temporal, and parietal cortex), cerebral association areas (frontal and visual association), basal ganglia (lenticular and thalamus), and posterior fossa (brain stem and cerebellar cortex). Subjects were grouped by age (< 1, 1 to < 3, 3 to < 8, and > or = 8 years), and the absolute values of the parameters were compared with those obtained from 10 healthy adults. RESULTS: rCBF and rCMRO2 were lower in the neonatal period than in older children and adults, and increased significantly during early childhood. rCBF was higher as compared with adults, peaking around age 7, whereas rCMRO2 was relatively high, with the last area to increase being the frontal association cortex. Both rCBF and rCMRO2 reached adult values during adolescence. No difference in rCBF was observed between the basal ganglia and the primary cerebral cortex; however, it was prominent in the occipital lobe in every age bracket. No significant changes in rOEF were found during childhood. CONCLUSION: The dynamic changes of rCBF and rCMRO2 observed in children probably reflect the physiologic developmental state within anatomic areas of the brain.

Developmental changes of cerebral blood flow and oxygen metabolism in children. Publishing Authors By Initials

T Takahashi,R Shirane,S Sato,T Yoshimoto,

For similar tomography, emission-computed research abstracts see: tomography, emission-computed research

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MEDLINE DATE:

Developmental changes of cerebral blood flow and oxygen metabolism in children. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: AJNR. American journal of neuroradiology

VOLUME: 20

Page Numbers: 917-22

Journal Abbreviation:

ISSN: 0195-6108

DAY: 14

MONTH: May

YEAR: 1999

Developmental changes of cerebral blood flow and oxygen metabolism in children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8003708

Developmental changes of cerebral blood flow and oxygen metabolism in children. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed

MESH TERMS: metabolism

Chemical & Substance for Abstract: Developmental changes of cerebral blood flow and oxygen metabolism in children. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Developmental changes of cerebral blood flow and oxygen metabolism in children.

AFFILIATION: Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.

Country: UNITED STATES

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MEDLINETA: AJNR Am J Neuroradiol

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