Developmental changes in progenitor cell responsiveness to cytokines.

Developmental changes in progenitor cell responsiveness to cytokines. Research Abstract Details 

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Developmental changes in progenitor cell responsiveness to cytokines. Abstract Text:

G Zhu,M F Mehler,P C Mabie,J A Kessler,

Multipotent progenitor cells have been identified within periventricular generative zones of the developing and adult brain. To determine whether the environmental responsiveness of these cells changes during development, progenitor cells were cultured from embryonic, postnatal, and adult rat brain in the presence of either basic fibroblast growth factor (bFGF) or epidermal growth factor (EGF). Embryonic cells cultured as intact progenitor neurospheres proliferated more robustly in response to bFGF than to EGF, whereas proliferation of postnatal and adult progenitor cells was enhanced more by EGF than bFGF. Progenitor cells generated in the presence of either bFGF or EGF had the capacity to generate neurons, astrocytes, and oligodendrocytes at all developmental stages. Most embryonic and neonatal bFGF-generated cells differentiated predominantly into neurons, whereas late stage embryonic and neonatal EGF-generated progenitors largely remained in an undifferentiated state. However, later postnatal and adult progenitor species, irrespective of whether they were generated in the presence of bFGF or EGF, gave rise preferentially to astrocytes. Treatment with bone morphogenetic protein (BMP)2 or BMP7 enhanced astroglial differentiation and suppressed oligodendroglial differentiation of both EGF- and bFGF-generated progenitor species, suggesting that the effects of the BMPs are not dependent on EGF receptor activation. Thus, while central nervous system (CNS) progenitor cells retain multipotent capacity and responsiveness to the BMPs throughout development, they exhibit significant changes in other cellular response properties, perhaps reflecting differences in the requirements for specific generative versus regenerative events.

Developmental changes in progenitor cell responsiveness to cytokines. Publishing Authors By Initials

G Zhu,MF Mehler,PC Mabie,JA Kessler,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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MEDLINE DATE:

Developmental changes in progenitor cell responsiveness to cytokines. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of neuroscience research

VOLUME: 56

Page Numbers: 131-45

Journal Abbreviation: J. Neurosci. Res.

ISSN: 0360-4012

DAY: 15

MONTH: Apr

YEAR: 1999

Developmental changes in progenitor cell responsiveness to cytokines. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7600111

Developmental changes in progenitor cell responsiveness to cytokines. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Developmental changes in progenitor cell responsiveness to cytokines. Information

Substance Name: Epidermal Growth Factor

Registry Number: 62229-50-9

Grant and Affiliation Information for Developmental changes in progenitor cell responsiveness to cytokines.

AFFILIATION: Departments of Neurology and Neuroscience, Albert Einstein College of Medicine, Bronx, New York, USA. gzhu@aecom.yu.edu

Country: UNITED STATES

AGENCY: United States NINDS

GRANT: NS35320

ACRONYM: NS

MEDLINETA: J Neurosci Res

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