Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing.

Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Research Abstract Details 

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Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Abstract Text:

K E Binns,T E Salt,

N-methyl-D-aspartate (NMDA) receptor-mediated activity is considered important for experience-dependent plasticity in the developing visual system. We investigated the influence of age and experience on the role of NMDA receptors in the visual transmission in the superficial grey layer of the superior colliculus (SGS) of the superior colliculus, where, in the adult, NMDA receptors mediate a substantial part of the visual response. In normally reared (postnatal day 14, P14, to adult) rats, visual responses were challenged with NMDA receptor-selective iontophoretic applications of the antagonist D-2-amino-5-phosphonovalerate (AP5). After eye opening (at P14), there was a significant increase in the number of neurones whose visual responses were reduced during AP5 ejection, which peaked at P22 (85%; n = 21), and then declined to adult levels (66%; n = 47) at P25. The mean reduction of the response (from control levels) by AP5 was similar at all ages (approximately 40%). Dark rearing had striking effects on the role of NMDA receptors in visual transmission, especially when comparisons were made between age-matched subjects greater than P25. In these subjects, AP5 ejection reduced the visual responses of all neurones studied. In addition, AP5 ejection caused a significantly larger reduction of visual responses in dark-reared rats (mean reduction 62 +/- 4; n = 29) compared with age-matched controls (mean reduction 44 +/- 8; n = 23). The D,L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) reduced the visual responses of every neurone studied and there were no age- or experience-dependent effects. We conclude that NMDA receptors, but not AMPA receptors, assume greater importance for visual transmission in the SGS of dark-reared rats.

Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Publishing Authors By Initials

KE Binns,TE Salt,

For similar sensation: vision research abstracts see: sensation: vision research

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Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 120

Page Numbers: 335-44

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: Jun

YEAR: 1998

Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Keywords Mesh Terms:

KEYWORDS: Vision

MESH TERMS: physiology

Chemical & Substance for Abstract: Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing. Information

Substance Name: 2-Amino-5-phosphonovalerate

Registry Number: 76726-92-6

Grant and Affiliation Information for Developmental changes in NMDA receptor-mediated visual activity in the rat superior colliculus, and the effect of dark rearing.

AFFILIATION: Department of Visual Science, Institute of Ophthalmology, University College London, UK. K.Binns@UCL.ac.uk

Country: GERMANY

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MEDLINETA: Exp Brain Res

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