Developmental changes in alpha-tocopherol, especially during infantile period.

Developmental changes in alpha-tocopherol, especially during infantile period. Research Abstract Details 

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Developmental changes in alpha-tocopherol, especially during infantile period. Abstract Text:

H Tamai,H S Kim,H Arai,K Inoue,M Mino,

Developmental changes in expression of alpha-TTP after birth were investigated using rats with respect to plasma changes of tocopherols. The expression of alpha-TTP in the neonatal rat liver, which was very low immediately after birth, increased steadily during the two weeks of life before weanling and reached the adult level at 4 weeks. During the suckling period, the plasma ratio of alpha-tocopherol to gamma-tocopherol linearly increased, because plasma alpha-tocopherol was low immediately after birth, increased rapidly during the period, while gamma-tocopherol remained unchanged. The increase in the ratio seemed to correlate with the developmental expression of alpha-TTP in the liver during this period. The ratio also reached the adult level after 4 weeks. The expression of alpha-TTP was investigated using primary cultured rat hepatocytes. The expression of alpha-TTP was found to be extremely low after 20 h of culture. The decrease in alpha-TTP expression was exacerbated by adding epidermal growth factor to the culture medium and was inhibited by adding dexamethasone. These observations suggest that expression of alpha-TTP may be affected by the state of hepatic differentiation. The Western and Northern blot analysis of alpha-TTP in vitamin E deficient and enriched rats were compared to control rats. The decrease of mRNA of alpha-TTP observed in alpha-Toc-enriched rat liver and the increase of mRNA observed in the vitamin E deficient rat liver indicate the synthesis of alpha-TTP, although alpha-TTP itself was not altered.

Developmental changes in alpha-tocopherol, especially during infantile period. Publishing Authors By Initials

H Tamai,HS Kim,H Arai,K Inoue,M Mino,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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Developmental changes in alpha-tocopherol, especially during infantile period. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua Minguo xiao er ke yi xue hui za zhi [Jour

VOLUME: 38

Page Numbers: 429-31

Journal Abbreviation:

ISSN: 0001-6578

DAY: 12

MONTH: 02

YEAR: 2008

Developmental changes in alpha-tocopherol, especially during infantile period. Information

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LANGUAGE: eng

NlmUniqueID: 16210470

Developmental changes in alpha-tocopherol, especially during infantile period. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: metabolism

Chemical & Substance for Abstract: Developmental changes in alpha-tocopherol, especially during infantile period. Information

Substance Name: Vitamin E

Registry Number: 1406-18-4

Grant and Affiliation Information for Developmental changes in alpha-tocopherol, especially during infantile period.

AFFILIATION: Department of Pediatrics, Osaka Medical College, Japan.

Country: TAIWAN

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MEDLINETA: Zhonghua Min Guo Xiao Er Ke Yi

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