Developmental autonomy and somatic niche construction promotes robust cell fate decisions.

Developmental autonomy and somatic niche construction promotes robust cell fate decisions. Research Abstract Details 

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Developmental autonomy and somatic niche construction promotes robust cell fate decisions. Abstract Text:

During the course of development cells undergo division producing a variety of cell types. Proliferation and differentiation are dependent on both genetic programs, encoded by the cellular genome, and environmental cues produced by the local cellular environment imposing local selection pressures on cells. We explore the role that cellular signals play over a large range of potential parameter regimes, in minimizing developmental error: errors in differentiation where an inappropriate proportion of differentiated daughter cells are generated. We find that trophic factors produced by the population of dividing cells can compensate for increased error rates when signals act through a form of positive feedback-survival signals. We operationalize these signals as the somatic niche and refer to their production as somatic niche construction. We find that tissue development switches to an autonomous state, independent of cellular signals, when errors are unmanageably high or density regulation is very strong. A signal-selective regime-strong niche dependence-is favored at low to intermediate error, assuming compartmentalized density dependence.

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Developmental autonomy and somatic niche construction promotes robust cell fate decisions. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of theoretical biology

VOLUME: 254

Page Numbers: 408-16

Journal Abbreviation: J. Theor. Biol.

ISSN: 1095-8541

DAY: 24

MONTH: 05

YEAR: 2008

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LANGUAGE: eng

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Grant and Affiliation Information for Developmental autonomy and somatic niche construction promotes robust cell fate decisions.

AFFILIATION: Department of Pathology, Stanford University Medical Center, Stanford, CA 94305, USA; Department of Developmental Biology, Stanford University Medical Center, Stanford, CA 94305, USA; Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA.

Country: Netherlands

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MEDLINETA: J Theor Biol

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