Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice.

Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Research Abstract Details 

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Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Abstract Text:

X Zhao,K Araki,J Miyazaki,K Yamamura,

Transgenic mice were produced by microinjection of a human serum amyloid P component (hSAP) gene or a fusion gene (SS) comprising the promoter for hSAP (nucleotides -600 to -14 from the start codon) and the coding region of the hepatitis B virus surface antigen (HBsAg). In adult mice, both transgenes were expressed only in the liver, and thus the pattern of expression resembled that of the endogenous mouse SAP gene. Both hSAP mRNA and HBsAg were first detected in liver on the second postnatal day. The level of these products increased rapidly and reached the maximum within the first week. These results suggest that the hSAP gene contains a short, cis-acting, developmental, and liver-specific regulatory sequence at the 5' or the 3' end and that this sequence can target expression of the foreign gene.

Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Publishing Authors By Initials

X Zhao,K Araki,J Miyazaki,K Yamamura,

For similar serum amyloid p-component research abstracts see: serum amyloid p-component research

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Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 111

Page Numbers: 736-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jun

YEAR: 1992

Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Keywords Mesh Terms:

KEYWORDS: Serum Amyloid P-Component

MESH TERMS: genetics

Chemical & Substance for Abstract: Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice. Information

Substance Name: Serum Amyloid P-Component

Registry Number: 0

Grant and Affiliation Information for Developmental and liver-specific expression directed by the serum amyloid P component promoter in transgenic mice.

AFFILIATION: Institute for Medical Genetics, Kumamoto University Medical School.

Country: JAPAN

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MEDLINETA: J Biochem

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