Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment.

Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment. Research Abstract Details 

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Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment. Abstract Text:

Victoria V Cheung,Awadhesh Jha,Richard Owen,Michael H Depledge,Tamara S Galloway,Victoria V Cheung,Awadhesh Jha,Richard Owen,Michael H Depledge,Tamara S Galloway,

Bioassay methods currently used to assess the toxicity of effluents, transitional and marine waters measure endpoints such as larval immobilisation or mortality, however, they offer limited data regarding important sub-lethal effects, including genotoxicity. The metaphase chromosome aberration (CAb) assay is routinely used in mammalian systems for testing samples for genotoxicity. In the current study, an in vivo CAb test system has been developed and optimised for use with the early (embryo-larval) life stages of the Pacific oyster Crassostrea gigas, a species used routinely in both effluent hazard assessment and marine environmental monitoring programmes. The method was validated with two reference mutagens: Methylmethanesulfonate, a direct acting mutagen; and benzo[a]pyrene an indirect acting reference mutagen.

Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment. Publishing Authors By Initials

VV Cheung,A Jha,R Owen,MH Depledge,TS Galloway,VV Cheung,A Jha,R Owen,MH Depledge,TS Galloway,

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Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Marine environmental research

VOLUME: 62 Suppl

Page Numbers: S278-82

Journal Abbreviation: Mar. Environ. Res.

ISSN: 0141-1136

DAY: 18

MONTH: 04

YEAR: 2006

Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment. Information

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LANGUAGE: eng

NlmUniqueID: 9882895

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Grant and Affiliation Information for Development of the in vivo chromosome aberration assay in oyster (Crassostrea gigas) embryo-larvae for genotoxicity assessment.

AFFILIATION: School of Biological Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA, UK.

Country: England

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MEDLINETA: Mar Environ Res

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