Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption.

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Abstract Text:

Yoshio Hayashi,Kentaro Takayama,Yuka Suehisa,Takuya Fujita,Jeffrey-Tri Nguyen,Shiroh Futaki,Akira Yamamoto,Yoshiaki Kiso,Yoshio Hayashi,Kentaro Takayama,Yuka Suehisa,Takuya Fujita,Jeffrey-Tri Nguyen,Shiroh Futaki,Akira Yamamoto,Yoshiaki Kiso,

We designed and synthesized new peptidic self-cleavable spacers that released a parent drug via succinimide formation and the oligoarginine-based cargo-transporter (OACT) system. The self-cleavable efficacy of these compounds was studied and the conversion time was controlled by an amino acid side-chain structure next to the succinyl moiety on the spacer. These novel self-cleavable spacers are promising for developments of the OACT system as means to potentially enhance intestinal absorption of parent drugs.

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Publishing Authors By Initials

Y Hayashi,K Takayama,Y Suehisa,T Fujita,JT Nguyen,S Futaki,A Yamamoto,Y Kiso,Y Hayashi,K Takayama,Y Suehisa,T Fujita,JT Nguyen,S Futaki,A Yamamoto,Y Kiso,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioorganic & medicinal chemistry letters

VOLUME: 17

Page Numbers: 5129-32

Journal Abbreviation: Bioorg. Med. Chem. Lett.

ISSN: 0960-894X

DAY: 7

MONTH: 07

YEAR: 2007

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107377

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption.

AFFILIATION: Department of Medicinal Chemistry, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192-0392, Japan. yhayashi@ps.toyaku.ac.jp

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption Related Publications

• "Click peptide" based on the "o-acyl isopeptide method": control of A beta1-42 production from a photo-triggered A beta1-42 analogue.
• 'O-Acyl isopeptide method' for peptide synthesis: Solvent effects in the synthesis of Abeta1-42 isopeptide using 'O-acyl isodipeptide unit'.
• Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1/Th2 Immunobalance and Induction of IL-10 Production.
• Application of the o-N intramolecular acyl migration reaction in medicinal chemistry.
• BACE1 inhibitors: optimization by replacing the P1' residue with non-acidic moiety.
• Design and synthesis of versatile ganglioside probes for carbohydrate microarrays.
• Design, synthesis, and biological evaluation of human sialidase inhibitors. Part 1: Selective inhibitors of lysosomal sialidase (NEU1).
• Design, synthesis, and biophysical properties of a helical Abeta1-42 analog: Inhibition of fibrillogenesis and cytotoxicity.
• Development of novel water-soluble photocleavable protective group and its application for design of photoresponsive paclitaxel prodrugs.
• Development of oligoarginine-drug conjugates linked to new peptidic self-cleavable spacers toward effective intestinal absorption.
• Effects of leukemia inhibitory factor on lectin-binding patterns in the uterine stromal vessels of mice.
• Fmoc-based solid phase chemical synthesis of 71-meric neuregulin 1-beta1, an epidermal growth factor-like domain.
• Insecticidal activity and biodegradability of lindane analogs.
• Novel non-peptidic and small-sized BACE1 inhibitors.
• Oral Administration of Dihomo-gamma-Linolenic Acid Prevents Development of Atopic Dermatitis in NC/Nga Mice.
• Self-recognition of N-linked glycans with multivalent GlcNAc, determined as ceramide mimetic conjugate.
• Structure of main globoside of human erythrocytes.
• Synthesis and activity of tetrapeptidic HTLV-I protease inhibitors possessing different P3-cap moieties.
• Total synthesis of 6-O-sulfo-sialylparagloboside: a widely useful glycoprobe for biochemical research.
• Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors.
• Upregulation of Indian hedgehog gene in the uterine epithelium by leukemia inhibitory factor during mouse implantation.
• [An approach to the targeted attachment of peptides and proteins to solid supports]
• [Clinical evaluation of surgical treatment of coronary disease]
• [Experimental studies of coronary arteriovenous anastomosis method (surgical therapy of ischemic heart disease)]
• [Influence of open heart surgery on myocardial performance evaluation of early postoperative left ventricular function and its reserve by atrial pacing exercise (author's transl)]
• [Intra-aortic balloon pumping. Physiological considerations and clinical application]
• [Myocardial protection during aorto-coronary bypass surgery]
• [Protease inhibitors]
• [Surgical treatment of inflammatory thoraco-abdominal aortic aneurysms]
• [Surgical treatment of primary malignant lymphoma of the lung (author's transl)]