Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity.

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity. Research Abstract Details 

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Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity. Abstract Text:

Weizhu Qian,Ling Wang,Bohua Li,Hao Wang,Sheng Hou,Xueyu Hong,Dapeng Zhang,Yajun Guo,Weizhu Qian,Ling Wang,Bohua Li,Hao Wang,Sheng Hou,Xueyu Hong,Dapeng Zhang,Yajun Guo,

Despite the widespread clinical use of CD34 antibodies for the purification of human hematopoietic stem/progenitor cells, all the current anti-human CD34 monoclonal antibodies (mAbs) are murine, which have the potential to elicit human antimouse antibody (HAMA) immune response. In the present study, we developed three new mouse anti-human CD34 mAbs which, respectively, belonged to class I, class II and class III CD34 epitope antibodies. In an attempt to reduce the immunogenicity of these three murine mAbs, their chimeric antibodies, which consisted of mouse antibody variable regions fused genetically to human antibody constant regions, were constructed and characterized. The anti-CD34 chimeric antibodies were shown to possess affinity and specificity similar to that of their respective parental murine antibodies. Due to the potentially better safety profiles, these chimeric antibodies might become alternatives to mouse anti-CD34 antibodies routinely used for clinical application.

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity. Publishing Authors By Initials

W Qian,L Wang,B Li,H Wang,S Hou,X Hong,D Zhang,Y Guo,W Qian,L Wang,B Li,H Wang,S Hou,X Hong,D Zhang,Y Guo,

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Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 367

Page Numbers: 497-502

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 9

MONTH: 01

YEAR: 2008

Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Development of new versions of anti-human CD34 monoclonal antibodies with potentially reduced immunogenicity.

AFFILIATION: International Joint Cancer Institute, Second Military Medical University, 800 Xiangyin Road, Shanghai 200433, People's Republic of China.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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