Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors.

Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Research Abstract Details 

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Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Abstract Text:

Hidenori Nonaka,Minoru Tanaka,Kaori Suzuki,Atsushi Miyajima,

Endothelial cells (ECs) display distinct structural and functional characteristics depending on the tissue and developmental stage; however, the development of tissue-specific ECs remains poorly understood. Here, we describe the development of hepatic sinusoids in mice based on the expression of hyaluronan receptors Stab2 and Lyve-1. Flk-1(+) cells in and around the liver bud begin to express Stab2 at embryonic day (E) 9.5, before the formation of vascular lumen. Hepatic sinusoidal endothelial cells (HSECs) begin to express Lyve-1 at E10.5, and both markers continue to be expressed in HSECs thereafter. Although HSECs and lymphatic ECs (LECs) are known to share functional and phenotypic characteristics, we clearly show that HSECs can be distinguished from LECs by the expression of molecular markers and higher endocytotic activity. Our results provide new insight into the development of tissue-specific ECs and phenotypic criteria to distinguish HSECs from other types of ECs, including LECs.

Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Publishing Authors By Initials

H Nonaka,M Tanaka,K Suzuki,A Miyajima,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: mice research

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Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Developmental dynamics : an official publication o

VOLUME: 236

Page Numbers: 2258-67

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 28

MONTH: Aug

YEAR: 2007

Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Information

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LANGUAGE: eng

NlmUniqueID: 9201927

Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Keywords Mesh Terms:

KEYWORDS: Mice

MESH TERMS: embryology

Chemical & Substance for Abstract: Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors. Information

Substance Name: Xlkd1 protein, mouse

Registry Number: 0

Grant and Affiliation Information for Development of murine hepatic sinusoidal endothelial cells characterized by the expression of hyaluronan receptors.

AFFILIATION: Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.

Country: United States

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MEDLINETA: Dev Dyn

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