Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Research Abstract Details 

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Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Abstract Text:

Federica Gemignani,Stefano Landi,Neonilia Szeszenia-Dabrowska,David Zaridze,Jolanta Lissowska,Peter Rudnai,Eleonora Fabianova,Dana Mates,Lenka Foretova,Vladimir Janout,Vladimir Bencko, Gaborieau,Lydie Gioia-Patricola,Ilaria Bellini,Roberto Barale,Federico Canzian,Janet Hall,Paolo Boffetta,Rayjean J Hung,Paul Brennan,

The role of genes coding for xenobiotic metabolizing enzymes (XMEs) and the risk of lung cancer is unclear. Under the assumption that these genes may be more important among people having a diagnosis of lung cancer at younger ages, we have investigated the role of single-nucleotide polymorphisms (SNPs) within phase I and phase II XME genes, and also genes involved in the metabolism of nucleic acids in a series of young onset patients and matched controls. We genotyped 299 lung cancer cases diagnosed before the age of 50 and 317 controls, from six countries of Central and Eastern Europe, by use of an oligonucleotide microarray and arrayed primer extension technique for 45 SNPs in 15 phase I XME genes, 46 SNPs in 17 phase II genes and 9 SNPs in 4 genes related to metabolism of nucleic acids. Heterozygote carriers of SNPs in CYP1A2 1545T>C, -164C>A and -740T>G; CYP2A6 -47A>C; MDR1 3435T>C; NAT1 1088T>A and 1095A>C; GSTA2 S112T; GSTM3 V224I and MTHFR A222V had altered risk of developing lung cancer. Phenotypes reconstructed after haplotype analyses showed that the carriers of the combined NAT1 fast+ NAT2 fast phenotypes were at lower risk when compared with those with the combined NAT1 slow + NAT2 slow acetylator phenotypes. Finally, extensive EPHX1 metabolizers showed an increased risk as compared with the poor metabolizers.

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Publishing Authors By Initials

F Gemignani,S Landi,N Szeszenia-Dabrowska,D Zaridze,J Lissowska,P Rudnai,E Fabianova,D Mates,L Foretova,V Janout,V Bencko,V Gaborieau,L Gioia-Patricola,I Bellini,R Barale,F Canzian,J Hall,P Boffetta,RJ Hung,P Brennan,

For similar pharmaceutical preparations: xenobiotics research abstracts see: pharmaceutical preparations: xenobiotics research

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Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Carcinogenesis

VOLUME: 28

Page Numbers: 1287-93

Journal Abbreviation: Carcinogenesis

ISSN: 0143-3334

DAY: 27

MONTH: 01

YEAR: 2007

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8008055

Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Keywords Mesh Terms:

KEYWORDS: Xenobiotics

MESH TERMS: metabolism

Chemical & Substance for Abstract: Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes. Information

Substance Name: Xenobiotics

Registry Number: 0

Grant and Affiliation Information for Development of lung cancer before the age of 50: the role of xenobiotic metabolizing genes.

AFFILIATION: Genetics, Department of Biology, University of Pisa, Pisa, Italy.

Country: England

AGENCY: United States NCI

GRANT: R01 CA092039-01A2

ACRONYM: CA

MEDLINETA: Carcinogenesis

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