Development of leptin-sensitive circuits.

Development of leptin-sensitive circuits. Research Abstract Details

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Development of leptin-sensitive circuits. Abstract Text:

S G Bouret,R B Simerly,

Energy homeostasis is achieved by the integration of peripheral metabolic signals by neural circuits. The organisation and function of neural circuits regulating energy homeostasis has been the subject of intense investigation and has led to the definition of a core circuitry in the hypothalamus that interacts with key regions in the brain stem, which appear to mediate many of the effects of the adipocyte-derived hormone leptin on feeding and energy balance. Recent data on the ontogeny of these pathways indicate that, in rodents, these feeding circuits primarily form during neonatal life and remain structurally and functionally immature until 3 weeks of life. Our understanding of the mechanisms promoting the formation of these critical circuits has been advanced significantly by recent evidence showing that neonatal leptin acts as a neurotrophic factor promoting the development of projections from the arcuate nucleus of the hypothalamus. Together with an expanding literature on the role of nutritional factors to affect health, these discoveries may contribute to our understanding on perinatally acquired predisposition to later disease, such as obesity and diabetes.

Development of leptin-sensitive circuits. Publishing Authors By Initials

SG Bouret,RB Simerly,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Development of leptin-sensitive circuits. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of neuroendocrinology

VOLUME: 19

Page Numbers: 575-82

Journal Abbreviation: J. Neuroendocrinol.

ISSN: 0953-8194

DAY: 3

MONTH: Aug

YEAR: 2007

Development of leptin-sensitive circuits. Information

Number of References: 70

LANGUAGE: eng

NlmUniqueID: 8913461

Development of leptin-sensitive circuits. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: drug effects

Chemical & Substance for Abstract: Development of leptin-sensitive circuits. Information

Substance Name: Leptin

Registry Number: 0

Grant and Affiliation Information for Development of leptin-sensitive circuits.

AFFILIATION: Neuroscience Program, The Saban Research Institute, Childrens Hospital Los Angeles and University of Southern California, Keck School of Medicine, Los Angeles, CA 90027, USA. sbouret@chla.usc.edu

Country: England