Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications.

Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Research Abstract Details 

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Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Abstract Text:

Lakshmi S Nair,Trevor Starnes,Jia-Wei Kevin Ko,Cato T Laurencin,Lakshmi S Nair,Trevor Starnes,Jia-Wei Kevin Ko,Cato T Laurencin,

Thermosetting polymers are attractive candidates for biomedical applications as noninvasive therapeutic delivery vehicles. In the present study, the feasibility of developing a neutral physiological temperature setting injectable formulation based on chitosan and an inorganic phosphate salt have been demonstrated. The in situ gelling system was developed by adding different concentrations of ammonium hydrogen phosphate (AHP) to chitosan solution. The resulting solutions have pH in the range of approximately 7-7.2. The gelling time of the chitosan-AHP solution was determined by incubating the solutions at 37 degrees C. Depending on the concentrations of AHP added, the gelling time varied from 5 min to 30 h at 37 degrees C. Addition of various diluents to chitosan-AHP solution did not significantly change the gelling time of the solutions. The gels were found to be cytocompatible as evidenced from in vitro cytocompatibility evaluation using MC3T3-E1 mouse osteoblast like cells. The feasibility of using the gels as a stem cell carrier vehicle as well as a macromolecular delivery vehicle has been demonstrated.

Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Publishing Authors By Initials

LS Nair,T Starnes,JW Ko,CT Laurencin,LS Nair,T Starnes,JW Ko,CT Laurencin,

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Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomacromolecules

VOLUME: 8

Page Numbers: 3779-85

Journal Abbreviation: Biomacromolecules

ISSN: 1525-7797

DAY: 10

MONTH: 11

YEAR: 2007

Development of injectable thermogelling chitosan-inorganic phosphate solutions for biomedical applications. Information

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LANGUAGE: eng

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AFFILIATION: Department of Orthopaedic Surgery, University of Virginia, Virginia 22903, Department of Biomedical Engineering, University of Virginia, Virginia 22908, and Department of Chemical Engineering, University of Virginia, Virginia 22904 nair@virginia.edu.

Country: United States

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MEDLINETA: Biomacromolecules

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