Development of HIV protease inhibitors: a survey.

Development of HIV protease inhibitors: a survey. Research Abstract Details 

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Development of HIV protease inhibitors: a survey. Abstract Text:

In the treatment of infections caused by rapidly mutating viruses like human immunodeficiency virus (HIV), combination therapy with multiple drugs acting by different mechanisms offers several advantages over monotherapy. It may provide: synergistic effect, possible reduction of dosages and side-effects, and reduction of the chance of drug resistance. In the past few years, hundreds of HIV protease inhibitors have been synthesized and tested in order to overcome the limitations of reverse transcriptase inhibitors like zidovudine and others. In this review, emphasis is placed on the development of HIV protease inhibitors as antiviral agents against HIV, and structure-activity relationship analysis of saquinavir and related compounds. Limitations of some protease inhibitors and ways to overcome the shortcomings are presented. Among these many protease inhibitors five have been marketed during 1995-1999. They are saquinavir, ritonavir, indinavir, nelfinavir and amprenavir. Their different structural features, important physicochemical, pharmacokinetic and clinical profiles are presented in a table form for easy comparison. It is hoped that in the future new drugs based on additional mechanisms can be developed for the treatment of AIDS.

Development of HIV protease inhibitors: a survey. Publishing Authors By Initials

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: structure-activity relationship research

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Development of HIV protease inhibitors: a survey. Journal Published:

PUBLICATION TYPE: Review

Journal: Progress in drug research. Fortschritte der Arznei

VOLUME: Spec No

Page Numbers: 1-34

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ISSN: 0071-786X

DAY: 25

MONTH: 02

YEAR: 2001

Development of HIV protease inhibitors: a survey. Information

Number of References: 77

LANGUAGE: eng

NlmUniqueID: 1304021

Development of HIV protease inhibitors: a survey. Keywords Mesh Terms:

KEYWORDS: Structure-Activity Relationship

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Development of HIV protease inhibitors: a survey. Information

Substance Name: HIV Protease Inhibitors

Registry Number: 0

Grant and Affiliation Information for Development of HIV protease inhibitors: a survey.

AFFILIATION: Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles 90089-9121, USA.

Country: Switzerland

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MEDLINETA: Prog Drug Res

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