Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin.

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Abstract Text:

Studies in sodium-dependent models of hypertension have shown that arginine-vasopressin (AVP) plays an important role in the maintenance of blood pressure, predominantly through its vasoconstrictor action. In addition to AVP, the sympathetic nervous system (SNS) also acts to maintain blood pressure in high sodium one-kidney, figure-8 renal wrap hypertension. The purpose of this study was to determine if chronic blockade of vascular AVP (V1) receptors affected the induction of high sodium renal hypertension and the contribution of the SNS to the maintenance of blood pressure. Rats receiving chronic s.c. administration of a V1 antagonist, d(CH2)5Tyr(Me)AVP, or vehicle were subjected to renal wrapping or sham surgery, V1 receptor blockade was confirmed periodically by an 80 +/- 3% reduction of the pressor response to a bolus injection of 10 mU/kg of AVP. d(CH2)5Tyr(Me)AVP did not affect the development of hypertension or the associated changes in plasma sodium, potassium, osmolality and hematocrit. In renal-wrapped rats, ganglionic blockade caused a greater fall in blood pressure in animals treated with d(CH2)5Tyr(Me)AVP than in vehicle-treated animals. However, this apparent increase in SNS function was not responsible for the hypertension in d(CH2)5Tyr(Me)AVP-treated, renal-wrapped rats, inasmuch as ganglionic blockade lowered blood pressure a similar amount in normotensive d(CH2)5Tyr(Me)AVP-treated, sham-operated rats and blood pressure remained elevated after combined blockade of the SNS, AVP and the renin-angiotensin systems. These results indicated that chronic blockade of V1 receptors did not alter the induction of high sodium renal hypertension and the mechanism of the elevated blood pressure was not through an activation of the SNS or other neurohumoral mechanisms.

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of pharmacology and experimental thera

VOLUME: 238

Page Numbers: 492-6

Journal Abbreviation: J. Pharmacol. Exp. Ther.

ISSN: 0022-3565

DAY: 16

MONTH: Aug

YEAR: 1986

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376362

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: blood

Chemical & Substance for Abstract: Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin. Information

Substance Name: Sodium

Registry Number: 7440-23-5

Grant and Affiliation Information for Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin.

AFFILIATION:

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Pharmacol Exp Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin Related Publications

• Atrial flutter associated with acute myocardial infarction.
• Biventricular ICD implant using endocardial LV lead placement from the left subclavian vein approach and transseptal puncture via the transfemoral route.
• Clinical assessment of the risk for sudden cardiac death in patients with sickle cell anemia.
• Coincidence-anticipation accuracy across the life span.
• Considerations and variations of dentist-prescribed, home-applied vital tooth-bleaching techniques.
• Controlled E-field gradient coils for MRI.
• DRUG THERAPY OF HYPERTENSION.
• Development of high sodium renal hypertension during chronic blockade of the vascular effects of vasopressin.
• Effects of paraventricular nucleus lesions on chronic renal hypertension.
• Evaluation of internet websites marketing herbal weight-loss supplements to consumers.
• Extending the reach of the thoracodorsal artery perforator flap for coverage of the shoulder.
• Eye movement pattern and accuracy during perceptual-motor performance in young and old adults.
• Food production and food security.
• Inpatient community-based geriatric assessment reduces subsequent mortality.
• Key sources of imprecision in radiological emergency response assessments.
• Salvage of a Congested DIEP Flap: A New Technique.
• The bilateral DIEP flap: A method of bipedicled anastomosis to a single internal mammary artery and venae comitantes.
• The direct healthcare costs associated with ankylosing spondylitis patients attending a UK secondary care rheumatology unit.