Development of fatal colitis in FVB mice infected with Citrobacter rodentium.

Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Research Abstract Details 

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Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Abstract Text:

Diana Borenshtein,Prashant R Nambiar,Elizabeth B Groff,James G Fox,David B Schauer,

Citrobacter rodentium is the causative agent of transmissible murine colonic hyperplasia. The disease is characterized by severe but temporary epithelial hyperplasia with limited inflammation in the descending colon of adult mice on a variety of genetic backgrounds. The natural history of infection with this murine pathogen has been characterized in outbred Swiss Webster (SW) mice but not in the cognate inbred FVB strain. In contrast to subclinical infection in SW mice, 12-week-old FVB mice developed overt disease with significant weight loss and mortality beginning by 9 days postinoculation (dpi). By 21 dpi, more than 75% of infected FVB mice died or had to be euthanized, whereas no mortality developed in SW mice. Mortality in FVB mice was fully prevented by fluid therapy. Fecal shedding of bacteria was similar in both groups through 9 dpi; however, a slight but significant delay in bacterial clearance was observed in FVB mice by 12 to 18 dpi. SW mice developed hyperplasia with minimal inflammation in the descending colon. FVB mice developed epithelial cell hyperproliferation, severe inflammation with erosions and ulcers, and epithelial atypia by 6 dpi in the descending colon. In the majority of surviving FVB mice, colonic lesions, including epithelial atypia, were reversible, although a small percentage (5 to 7%) exhibited chronic colitis through 7 months postinoculation. The existence of susceptible and resistant lines of mice with similar genetic backgrounds will facilitate the identification of host factors responsible for the outcome of infection and may lead to the development of novel strategies for preventing and treating infectious colitis.

Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Publishing Authors By Initials

D Borenshtein,PR Nambiar,EB Groff,JG Fox,DB Schauer,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: germ-free life: specific pathogen-free organisms research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: germ-free life: specific pathogen-free organisms research

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Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Infection and immunity

VOLUME: 75

Page Numbers: 3271-81

Journal Abbreviation: Infect. Immun.

ISSN: 0019-9567

DAY: 30

MONTH: 04

YEAR: 2007

Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Information

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LANGUAGE: eng

NlmUniqueID: 246127

Development of fatal colitis in FVB mice infected with Citrobacter rodentium. Keywords Mesh Terms:

KEYWORDS: Specific Pathogen-Free Organisms

MESH TERMS: pathology

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Grant and Affiliation Information for Development of fatal colitis in FVB mice infected with Citrobacter rodentium.

AFFILIATION: Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: T32 ES 07020

ACRONYM: ES

MEDLINETA: Infect Immun

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