Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat.

Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat. Research Abstract Details 

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Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat. Abstract Text:

Kazunori Shimada,Toshinori Ito,Masahiro Tanemura,Hiroshi Komoda,Yuichi Fumimoto,Koichi Kawamoto,Toshirou Nishida,Hideaki Kaneto,Yoshiki Sawa,

BACKGROUND: We previously demonstrated the development of beta-cells in the native pancreas after syngeneic pancreas transplantation (PTx) in a model of type 2 diabetes, namely the Spontaneously Diabetic Torii (SDT; RT1(a)) rat. In this study, we evaluated the effect of fully allogeneic PTx (allo-PTx) under immunosuppression on the native pancreases in the recipients. MATERIALS AND METHODS: Diabetic 25-week-old SDT rats were divided into two groups: untreated controls and PTx-treated recipients. Dark Agouti (RT1(a)) pancreases were then transplanted into the SDT rats. FK506 was administered daily postoperatively. Each group was examined for 15 weeks. RESULTS: Control SDT rats showed a disappearance of the pancreatic and duodenal homeobox-1 (PDX-1) expression of the pancreases with the development of diabetes. In addition, the islets were gradually replaced by fibrosis, thus resulting in a marked decrease in the beta-cell mass at 40 weeks of age. On the other hand, in PTx recipients, islet-like cell clusters were found in the native pancreases. The beta-cell mass significantly increased in the native pancreases in the recipients at 10 and 15 weeks posttransplantation in comparison to the age-matched controls. Moreover, we observed the re-expression of PDX-1 in the islet-like cell clusters. Interestingly, insulin and glucagon double-positive stained cells in the mesenchyme and insulin single-positive cells in the ductal epithelium were also observed. CONCLUSIONS: Our results indicated that the benefits of avoiding glucose toxicity by allo-PTx under immunosuppression could therefore induce the PDX-1 expression in the native pancreases, thus potentially resulting in the development of beta-cells in type 2 diabetic recipients.

Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat. Publishing Authors By Initials

K Shimada,T Ito,M Tanemura,H Komoda,Y Fumimoto,K Kawamoto,T Nishida,H Kaneto,Y Sawa,

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Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of surgical research

VOLUME: 145

Page Numbers: 229-37

Journal Abbreviation: J. Surg. Res.

ISSN: 0022-4804

DAY: 30

MONTH: 08

YEAR: 2007

Development of beta-Cells in the Native Pancreas After Pancreas Allo-Transplantation in the Spontaneously Diabetic Torii Rat. Information

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LANGUAGE: eng

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AFFILIATION: Department of Surgery, Osaka University Graduate School of Medicine, Osaka, Japan.

Country: United States

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MEDLINETA: J Surg Res

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