Development of a transferrin receptor-targeting HVJ-E vector.

Development of a transferrin receptor-targeting HVJ-E vector. Research Abstract Details 

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Development of a transferrin receptor-targeting HVJ-E vector. Abstract Text:

Takashi Shimbo,Masako Kawachi,Kotaro Saga,Hiroshi Fujita,Takehiko Yamazaki,Katsuto Tamai,Yasufumi Kaneda,Takashi Shimbo,Masako Kawachi,Kotaro Saga,Hiroshi Fujita,Takehiko Yamazaki,Katsuto Tamai,Yasufumi Kaneda,

The development of more effective cancer treatments is anticipated. Tumor-targeted drug delivery is an important strategy in cancer therapy. We have developed an HVJ (hemagglutinating virus of Japan; Sendai virus) envelope (HVJ-E) vector using inactivated Sendai virus. The HVJ-E vector has been observed to target a number of cell lines since its hemagglutinin-neuraminidase (HN) protein recognizes the sialic acids of host cells. Thus, to reduce non-specific binding of the HVJ-E vector, we eliminated HN protein using HN-specific short interfering RNA (siRNA). Then, to further increase its tumor-targeting ability, we constructed HN-depleted HVJ containing the F-transferrin chimeric protein. The modified vectors containing Q-dots demonstrated 32-fold greater tumor-targeting efficiency than wild-type HVJ-E.

Development of a transferrin receptor-targeting HVJ-E vector. Publishing Authors By Initials

T Shimbo,M Kawachi,K Saga,H Fujita,T Yamazaki,K Tamai,Y Kaneda,T Shimbo,M Kawachi,K Saga,H Fujita,T Yamazaki,K Tamai,Y Kaneda,

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Development of a transferrin receptor-targeting HVJ-E vector. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 364

Page Numbers: 423-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 12

MONTH: 10

YEAR: 2007

Development of a transferrin receptor-targeting HVJ-E vector. Information

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LANGUAGE: eng

NlmUniqueID: 372516

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Grant and Affiliation Information for Development of a transferrin receptor-targeting HVJ-E vector.

AFFILIATION: Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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