Development of a specific fluorescent probe for 8-oxoguanosine.

Development of a specific fluorescent probe for 8-oxoguanosine. Research Abstract Details 

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Development of a specific fluorescent probe for 8-oxoguanosine. Abstract Text:

Sayaka Ono,Zhichun Li,Yohei Koga,Akira Tsujimoto,Osamu Nakagawa,Shigeki Sasaki,

8-Oxoguanosine (8-oxoG) is derived from the oxidation of guanosine (dG) and is known to induce transversion mutations (G:C to T:A) in DNA. We have already reported the fluorescent probe "8-oxoG-clamp", which shows a selective fluorescence quenching phenomenon toward 8-oxoG. In this study, attachment of an additional fluorophore to 8-oxoG-clamp was investigated as a strategy for the detection of 8-oxoG by a fluorescence color change attributed to the 8-oxoG-clamp.

Development of a specific fluorescent probe for 8-oxoguanosine. Publishing Authors By Initials

S Ono,Z Li,Y Koga,A Tsujimoto,O Nakagawa,S Sasaki,

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Development of a specific fluorescent probe for 8-oxoguanosine. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nucleic acids symposium series (2004)

VOLUME:

Page Numbers: 315-6

Journal Abbreviation: Nucleic Acids Symp Ser (Oxf)

ISSN: 1746-8272

DAY: 21

MONTH: 11

YEAR: 2007

Development of a specific fluorescent probe for 8-oxoguanosine. Information

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LANGUAGE: eng

NlmUniqueID: 101259965

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Grant and Affiliation Information for Development of a specific fluorescent probe for 8-oxoguanosine.

AFFILIATION: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.

Country: England

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MEDLINETA: Nucleic Acids Symp Ser (Oxf)

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