Development of a new in vitro model for the study of benign prostatic hyperplasia.

Development of a new in vitro model for the study of benign prostatic hyperplasia. Research Abstract Details 

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Development of a new in vitro model for the study of benign prostatic hyperplasia. Abstract Text:

F K Habib,M Ross,C W Bayne,

BACKGROUND: The search for novel agents for the treatment of the lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) is dependent on an increased understanding of the pathophysiology of the disease. Unfortunately, in vitro and animal models have been of limited value. METHODS: This article describes a novel model system in which the interactions of the stromal and epithelial components of the prostate gland can be determined. RESULTS: The coculture system provides a simple model of the cellular interactions occurring in the adult human prostate. CONCLUSIONS: This coculture system could potentially be used to determine the precise molecular site of action of agents such as terazosin on prostatic apoptosis.

Development of a new in vitro model for the study of benign prostatic hyperplasia. Publishing Authors By Initials

FK Habib,M Ross,CW Bayne,

For similar cells: connective tissue cells: stromal cells research abstracts see: cells: connective tissue cells: stromal cells research

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Development of a new in vitro model for the study of benign prostatic hyperplasia. Journal Published:

PUBLICATION TYPE: Review

Journal: The Prostate. Supplement

VOLUME: 9

Page Numbers: 15-20

Journal Abbreviation:

ISSN: 1050-5881

DAY: 12

MONTH: 02

YEAR: 2000

Development of a new in vitro model for the study of benign prostatic hyperplasia. Information

Number of References: 10

LANGUAGE: eng

NlmUniqueID: 9003050

Development of a new in vitro model for the study of benign prostatic hyperplasia. Keywords Mesh Terms:

KEYWORDS: Stromal Cells

MESH TERMS: physiology

Chemical & Substance for Abstract: Development of a new in vitro model for the study of benign prostatic hyperplasia. Information

Substance Name: terazosine

Registry Number: 63590-64-7

Grant and Affiliation Information for Development of a new in vitro model for the study of benign prostatic hyperplasia.

AFFILIATION: Prostate Research Group, University Department of Oncology, Western General Hospital, Edinburgh, Scotland, UK. fouad.habib@ed.ak.uk

Country: UNITED STATES

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MEDLINETA: Prostate Suppl

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