Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics.

Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics. Research Abstract Details 

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Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics. Abstract Text:

The identification of the calcium-sensing receptor (CaSR) and the clarification of its role as the major regulator of parathyroid gland function have important implications for understanding the pathogenesis and evolution of secondary hyperthyroidism in chronic kidney disease (CKD). Signaling through the CaSR has direct effects on three discrete components of parathyroid gland function, which include parathyroid hormone (PTH) secretion, PTH synthesis, and parathyroid gland hyperplasia. Disturbances in calcium and vitamin D metabolism that arise owing to CKD diminish the level of activation of the CaSR, leading to increases in PTH secretion, PTH synthesis, and parathyroid gland hyperplasia. Each represents a physiological adaptive response by the parathyroid glands to maintain plasma calcium homeostasis. Studies of genetically modified mice indicate that signal transduction via the CaSR is a key determinant of parathyroid cell proliferation and parathyroid gland hyperplasia. Because enlargement of the parathyroid glands has important implications for disease progression and disease severity, it is possible that clinical management strategies that maintain adequate calcium-dependent signaling through the CaSR will ultimately prove useful in diminishing parathyroid gland hyperplasia and in modifying disease progression.Kidney International (2008) 74, 276-288; doi:10.1038/sj.ki.5002287; published online 13 June 2007.

Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics. Publishing Authors By Initials

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Development and progression of secondary hyperparathyroidism in chronic kidney disease: lessons from molecular genetics. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Kidney international

VOLUME: 74

Page Numbers: 276-88

Journal Abbreviation: Kidney Int.

ISSN: 1523-1755

DAY: 13

MONTH: 06

YEAR: 2007

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LANGUAGE: eng

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AFFILIATION: 1Division of Nephrology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

Country: United States

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MEDLINETA: Kidney Int

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