Development and bioavailability assessment of ramipril nanoemulsion formulation.

Development and bioavailability assessment of ramipril nanoemulsion formulation. Research Abstract Details 

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Development and bioavailability assessment of ramipril nanoemulsion formulation. Abstract Text:

Sheikh Shafiq,Faiyaz Shakeel,Sushma Talegaonkar,Farhan J Ahmad,Roop K Khar,Mushir Ali,Sheikh Shafiq,Faiyaz Shakeel,Sushma Talegaonkar,Farhan J Ahmad,Roop K Khar,Mushir Ali,

The objective of our investigation was to design a thermodynamically stable and dilutable nanoemulsion formulation of Ramipril, with minimum surfactant concentration that could improve its solubility, stability and oral bioavailability. Formulations were taken from the o/w nanoemulsion region of phase diagrams, which were subjected to thermodynamic stability and dispersibility tests. The composition of optimized formulation was Sefsol 218 (20% w/w), Tween 80 (18% w/w), Carbitol (18% w/w) and standard buffer solution pH 5 (44% w/w) as oil, surfactant, cosurfactant and aqueous phase, respectively, containing 5 mg of ramipril showing drug release (95%), droplet size (80.9 nm), polydispersity (0.271), viscosity (10.68 cP), and infinite dilution capability. In vitro drug release of the nanoemulsion formulations was highly significant (p<0.01) as compared to marketed capsule formulation and drug suspension. The relative bioavailability of ramipril nanoemulsion to that of conventional capsule form was found to be 229.62% whereas to that of drug suspension was 539.49%. The present study revealed that ramipril nanoemulsion could be used as a liquid formulation for pediatric and geriatric patients and can be formulated as self-nanoemulsifying drug delivery system (SNEDDS) as a unit dosage form.

Development and bioavailability assessment of ramipril nanoemulsion formulation. Publishing Authors By Initials

S Shafiq,F Shakeel,S Talegaonkar,FJ Ahmad,RK Khar,M Ali,S Shafiq,F Shakeel,S Talegaonkar,FJ Ahmad,RK Khar,M Ali,

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Development and bioavailability assessment of ramipril nanoemulsion formulation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of pharmaceutics and biopharmaceu

VOLUME: 66

Page Numbers: 227-43

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ISSN: 0939-6411

DAY: 24

MONTH: 10

YEAR: 2006

Development and bioavailability assessment of ramipril nanoemulsion formulation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Development and bioavailability assessment of ramipril nanoemulsion formulation.

AFFILIATION: Department of Pharmaceutics, Jamia Hamdard, Hamdard Nagar, India. shafiq_sheikh@fastmail.fm

Country: Netherlands

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MEDLINETA: Eur J Pharm Biopharm

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