Developing synthetic conical nanopores for biosensing applications.

Developing synthetic conical nanopores for biosensing applications. Research Abstract Details 

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Developing synthetic conical nanopores for biosensing applications. Abstract Text:

Lindsay T Sexton,Lloyd P Horne,Charles R Martin,

In this review we bring together recent results from our group focused towards the development of biosensors from single conically-shaped artificial nanopores. The nanopores, used in the work presented here, were prepared using the track-etch process. The fabrication of track-etched conical nanopores has been optimized to allow for single nanopores with reproducible dimensions to be prepared. We have also demonstrated techniques that allow for easy and controllable manipulation of nanopore geometry (e.g., cone angle). We will consider the ion transport properties of the conical nanopores and factors that affect these properties. Methods for introducing functions that mimic biological ion channels, such as voltage-gating, into these nanopores will also be addressed. Three prototype sensors developed from single conical nanopores will be presented. In the first two sensors, the single conical nanopores function as resistive-pulse sensors and detect the presence of analytes as current-blockade events in the ion current. The third sensor functions in an on/off mode, much like a ligand-gated ion channel. In the presence of a target analyte, the ion current permanently shuts off.

Developing synthetic conical nanopores for biosensing applications. Publishing Authors By Initials

LT Sexton,LP Horne,CR Martin,

For similar proteins research abstracts see: proteins research

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Developing synthetic conical nanopores for biosensing applications. Journal Published:

PUBLICATION TYPE: Review

Journal: Molecular bioSystems

VOLUME: 3

Page Numbers: 667-85

Journal Abbreviation: Mol Biosyst

ISSN: 1742-206X

DAY: 3

MONTH: 09

YEAR: 2007

Developing synthetic conical nanopores for biosensing applications. Information

Number of References: 96

LANGUAGE: eng

NlmUniqueID: 101251620

Developing synthetic conical nanopores for biosensing applications. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: analysis

Chemical & Substance for Abstract: Developing synthetic conical nanopores for biosensing applications. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Developing synthetic conical nanopores for biosensing applications.

AFFILIATION: Department of Chemistry and Center for Research at the Bio/Nano Interface, University of Florida, Gainesville, FL 32611-7200, USA.

Country: England

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MEDLINETA: Mol Biosyst

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