Detrimental and protective bystander effects: a model approach.

Detrimental and protective bystander effects: a model approach. Research Abstract Details 

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Detrimental and protective bystander effects: a model approach. Abstract Text:

H ,R E J Mitchel,J L Redpath,D J Crawford-Brown,W Hofmann,H ,R E J Mitchel,J L Redpath,D J Crawford-Brown,W Hofmann,

This work integrates two important cellular responses to low doses, detrimental bystander effects and apoptosis-mediated protective bystander effects, into a multistage model for chromosome aberrations and in vitro neoplastic transformation: the State-Vector Model. The new models were tested on representative data sets that show supralinear or U-shaped dose responses. The original model without the new low-dose features was also tested for consistency with LNT-shaped dose responses. Reductions of in vitro neoplastic transformation frequencies below the spontaneous level have been reported after exposure of cells to low doses of low-LET radiation. In the current study, this protective effect is explained with bystander-induced apoptosis. An important data set that shows a low-dose detrimental bystander effect for chromosome aberrations was successfully fitted by additional terms within the cell initiation stage. It was found that this approach is equivalent to bystander-induced clonal expansion of initiated cells. This study is an important step toward a comprehensive model that contains all essential biological mechanisms that can influence dose-response curves at low doses.

Detrimental and protective bystander effects: a model approach. Publishing Authors By Initials

H ,RE Mitchel,JL Redpath,DJ Crawford-Brown,W Hofmann,H ,RE Mitchel,JL Redpath,DJ Crawford-Brown,W Hofmann,

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Detrimental and protective bystander effects: a model approach. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Radiation research

VOLUME: 168

Page Numbers: 614-26

Journal Abbreviation: Radiat. Res.

ISSN: 0033-7587

DAY: 1

MONTH: Nov

YEAR: 2007

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LANGUAGE: eng

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Grant and Affiliation Information for Detrimental and protective bystander effects: a model approach.

AFFILIATION: Department of Materials Engineering and Physics and Biophysics, University of Salzburg, Salzburg, Austria. helmut.schoellnberger@sbg.ac.at

Country: United States

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MEDLINETA: Radiat Res

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