Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry.

Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry. Research Abstract Details 

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Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry. Abstract Text:

This paper details a method for the separation and determination of ten benzodiazepines in urine using CEC-MS(TOF) and an hexyl acrylate-based porous monolith. The TOF mass spectrometer provides an exact mass of protonated benzodiazepines to three decimal places (1-6 ppm). This high selectivity along with the CEC separation, provides an effective method for the identification of benzodiazepines. Linearity is satisfactory for all compounds in the concentration range of 25-500 ng/mL for lorazepam and 12.5-500 ng/mL for the others. The RSDs are between 1.4-2.3% for retention times and 1.1-9.2% for relative areas. Using the monolithic stationary phase, a preconcentration step is achievable and permits an 75-140-fold improvement in sensitivity. This strategy permits the quantification of these drugs down to 1 ng/mL in urine. This method was used for the analysis of benzodiazepines in spiked urine samples.

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Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Electrophoresis

VOLUME: 29

Page Numbers: 2182-92

Journal Abbreviation: Electrophoresis

ISSN: 0173-0835

DAY: 26

MONTH: May

YEAR: 2008

Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry. Information

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LANGUAGE: eng

NlmUniqueID: 8204476

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Grant and Affiliation Information for Determination of trace levels of benzodiazepine in urine using capillary electrochromatography-time of flight mass spectrometry.

AFFILIATION: Chemistry Department, Florida International University, Miami, FL, USA.

Country: Germany

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MEDLINETA: Electrophoresis

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