[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema]

[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Research Abstract Details 

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[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Abstract Text:

S S Andina,L V Kozlov,V L D'iakov,

Aetiology of angioedema (and therefore the scheme of its treatment) can be different. Angioedema may be subdivided into four categories: hereditary and acquired angioedemas, allergies and vasculitis. To establish the reason of the hereditary and acquired form of angioedema analyses of functional activity of complement components, quantities and activity of C1 inhibitor, presence (or absence) autoantibodies to C1 inhibitor allow. Sorption of the puried enzymes of activated subcomponent C1s or plasmin on micropanels allows to connect specifically in cells of plate C1 inhibitor from serum and with the help conjugate of antibodies against C1 inhibitor with a horse-radish peroxidase to determine quantity of connected functionally active C1 inhibitor. Addition of this test-system ELISA system for determination of quantitative contents of C1 inhibitor in serum, and also systems for definition IgG, IgA and IgM autoantibodies against C1 inhibitor finishes creation of a necessary set of methods of differential diagnostics.

[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Publishing Authors By Initials

SS Andina,LV Kozlov,VL D'iakov,

For similar proteins: serpins research abstracts see: proteins: serpins research

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[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomedit?sinskai?a khimii?a

VOLUME: 50

Page Numbers: 86-91

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DAY: 3

MONTH: 04

YEAR: 2008

[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Information

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LANGUAGE: rus

NlmUniqueID: 101196966

[Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Keywords Mesh Terms:

KEYWORDS: Serpins

MESH TERMS: deficiency

Chemical & Substance for Abstract: [Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema] Information

Substance Name: Serpins

Registry Number: 0

Grant and Affiliation Information for [Determination of the functional activity, amount of C1 inhibitor, and autoantibodies as a tool for differential diagnosis of angioedema]

AFFILIATION: Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, Admirala Makarova, 10, Moscow, 125212 Russia.

Country: Russia

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MEDLINETA: Biomed Khim

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