Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation.

Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Research Abstract Details 

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Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Abstract Text:

R Dembczynski,T Jankowski,

The exclusion limit expressed as the largest pore size of capsules composed of hydrogel Ca-alginate membrane and hydroxy-propyl-ammonium starch liquid core considered as the immunoprotective system has been determined by means of inverse size exclusion chromatography with dextran molecular weight standards. The exclusion limits of the capsules were not influenced by the change of starch concentration in the core solution from 4 to 6% but were influenced by the change in alginate concentration in the membrane from 0.5 to 1.0%, causing the membranes to be less permeable. It was found that the diameter of the largest pores in hydrogel membranes was in the range 7.2-8.0 nm. Based on the relationship between solute size and its molecular weight, the capsules had an approximate exclusion limit of 21-25 kD for dextran and 78-103 kD for protein, which is sufficient to block the antibodies penetrating through the membrane.

Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Publishing Authors By Initials

R Dembczynski,T Jankowski,

For similar natural sciences: chemistry: chemistry, physical: molecular weight research abstracts see: natural sciences: chemistry: chemistry, physical: molecular weight research

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Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 12

Page Numbers: 1051-8

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2001

Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Keywords Mesh Terms:

KEYWORDS: Molecular Weight

MESH TERMS: chemistry

Chemical & Substance for Abstract: Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation. Information

Substance Name: alginic acid

Registry Number: 9005-32-7

Grant and Affiliation Information for Determination of pore diameter and molecular weight cut-off of hydrogel-membrane liquid-core capsules for immunoisolation.

AFFILIATION: Department of Biotechnology and Food Microbiology, Agricultural University of Poznan, Poland.

Country: Netherlands

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MEDLINETA: J Biomater Sci Polym Ed

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