Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial.

Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial. Research Abstract Details 

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Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial. Abstract Text:

OBJECTIVE: To examine the effectiveness of pH analysis of fetal scalp blood compared with lactate analysis in identifying hypoxia in labour to prevent acidaemia at birth. DESIGN: Randomised controlled multicentre trial. SETTING: Labour wards. PARTICIPANTS: Women with a singleton pregnancy, cephalic presentation, gestational age >or=34 weeks, and clinical indication for fetal scalp blood sampling. INTERVENTIONS: Standard pH analysis (n=1496) or lactate analysis (n=1496) with an electrochemical microvolume (5 mul) test strip device. The cut-off levels for intervention were pH <7.21 and lactate >4.8 mmol/l, respectively. MAIN OUTCOME MEASURE: Metabolic acidaemia (pH <7.05 and base deficit >12 mmol/l) or pH <7.00 in cord artery blood. RESULTS: Metabolic acidaemia occurred in 3.2% in the lactate group and in 3.6% in the pH group (relative risk 0.91, 95% confidence interval 0.61 to 1.36). pH <7.00 occurred in 1.5% in the lactate group and in 1.8% in the pH group (0.84, 0.47 to 1.50). There was no significant difference in Apgar scores <7 at 5 minutes (1.15, 0.76 to 1.75) or operative deliveries for fetal distress (1.02, 0.93 to 1.11). CONCLUSION: There were no significant differences in rate of acidaemia at birth after use of lactate analysis or pH analysis of fetal scalp blood samples to determine hypoxia during labour. TRIAL REGISTRATION: ISRCT No 1606064.

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Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: BMJ (Clinical research ed.)

VOLUME: 336

Page Numbers: 1284-7

Journal Abbreviation: BMJ

ISSN: 1468-5833

DAY: 25

MONTH: 05

YEAR: 2008

Determination of pH or lactate in fetal scalp blood in management of intrapartum fetal distress: randomised controlled multicentre trial. Information

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LANGUAGE: eng

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AFFILIATION: Departments of Obstetrics and Gynaecology Söder Hospital, Stockholm, Sweden.

Country: England

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