Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography.

Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography. Research Abstract Details 

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Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography. Abstract Text:

M A Ribick,M Jemal,A I Cohen,

A fused silica capillary gas chromatographic method is presented for the determination of traces of ethylenediaminetetra-acetic acid (EDTA) in aqueous rinses of rubber stoppers of pharmaceutical vials after treatment with detergents containing EDTA. Isolation and enrichment of EDTA from the aqueous medium is achieved using a commercially available strong anion-exchange solid-phase extraction cartridge, transformed to the formate form. A 2.0-ml volume of methanolic HCl is used for both elution of EDTA from the extraction column and formation of the tetramethyl ester derivative. With the incorporation of a methanolic wash to eliminate interfering components prior to elution with methanolic HCl, a limit of detection of 25 ng EDTA per ml water with a non-selective flame ionization detector is possible.

Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography. Publishing Authors By Initials

MA Ribick,M Jemal,AI Cohen,

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Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of pharmaceutical and biomedical analysis

VOLUME: 5

Page Numbers: 687-94

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ISSN: 0731-7085

DAY: 26

MONTH: 07

YEAR: 1987

Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography. Information

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LANGUAGE: eng

NlmUniqueID: 8309336

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Grant and Affiliation Information for Determination of ethylenediaminetetra-acetic acid in aqueous rinses of detergent-washed rubber stoppers of pharmaceutical vials using solid-phase extraction and capillary gas chromatography.

AFFILIATION: Squibb Institute for Medical Research, Analytical R & D Department, P.O. Box 191, New Brunswick, NJ 08903, USA.

Country: England

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MEDLINETA: J Pharm Biomed Anal

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