Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography.

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Abstract Text:

A Q Li,X L Zhao,

A capillary gas chromatographic method was developed for determining 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in the plasma and urine of cancer patients under pharmacokinetic study. The drug was extracted with ethyl acetate and methylated with diazomethane. Octadelane (10 microg/ml) was added as internal standard. The separation was carried out on an OV-1 quartz capillary column, 15 m x 0.32 mm (0.52 microm), with high-purity nitrogen as carrier gas and flame ionization detector (FID) as detector. The column temperature was held at 130 degrees C for 9 min and then programmed to 240 degrees C, at a rate of 35 degrees C/min. The temperature of both injector and detector was 260 degrees C. The standard curve was linear from 0.4 to 40 microg/mL in plasma, and from 0.8 to 20 microg/mL in urine, with correlation coefficients of 0.9979 and 0.9932. The relative standard deviations (RSD) were less than 9.7%. The minimum recovery of this method was 81.8%. This method was applied to the pharmacokinetic studies of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients after a single dose (i.v.) of 160, 420 or 760 mg/m(2) was administered. They all conformed to the two-compartment open model and showed linear pharmacokinetics. The excretion of this drug in the urine was minimal.

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Publishing Authors By Initials

AQ Li,XL Zhao,

For similar organic chemicals: triazenes research abstracts see: organic chemicals: triazenes research

PUBMED ID PMID:

MEDLINE DATE:

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biomedical chromatography : BMC

VOLUME: 15

Page Numbers: 75-8

Journal Abbreviation:

ISSN: 0269-3879

DAY: 15

MONTH: Apr

YEAR: 2001

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8610241

Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Keywords Mesh Terms:

KEYWORDS: Triazenes

MESH TERMS: urine

Chemical & Substance for Abstract: Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography. Information

Substance Name: 1-(4-carboxyphenyl)-3,3-dimethyltriazene

Registry Number: 7203-91-0

Grant and Affiliation Information for Determination and pharmacokinetic study of 1-p-(3.3-dimethyl-1-triazeno) benzoic acid in cancer patients by capillary gas chromatography.

AFFILIATION: Central Laboratory of Guangdong, Provincial Hospital of Traditional Chinese Medicine, 111 Dade Road, Guangzhou, People's Republic of China.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Biomed Chromatogr

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Determination and pharmacokinetic study of 1-p-33-dimethyl-1-triazeno benzoic acid in cancer patients by capillary gas chromatography Related Publications

• Cooperation of endoderm-derived BMP2 and extraembryonic ectoderm-derived BMP4 in primordial germ cell generation in the mouse.
• Effect of vitamin E succinate on expression of TGF-beta1, c-Jun and JNK1 in human gastric cancer SGC-7901 cells.
• Roles of Fas signaling pathway in vitamin E succinate-induced apoptosis in human gastric cancer SGC-7901 cells.
• Vascular osteomuscular autograft prefabrication using coral, type I collagen and recombinant human bone morphogenetic protein-2.
• [Acute physiology and chronic health evaluation II system to prevent and treat infection in surgical ICU]
• [An experimental study on the effect of xenogeneic bone combined with human recombinant bone morphogenetic protein-2]
• [Anterior instrumentation for the treatment of tuberculotic spinal deformity]
• [Arthrowand technique under arthroscope in diagnosis and treatment of knee disease]
• [Breast ptosis correction with a knitted polypropylene mesh]
• [Changes in autoantibody against cardiovascular AT1-receptor during development of renovascular hypertension in rats]
• [Characters of uncoupling protein and its relation with obesity]
• [Classification and treatment of asymmetrical breast deformity]
• [Clinical analysis of 44 cases of recurrent thyroid carcinoma]
• [Clinico-pathologic and prognostic studies on lung adenocarcinoma patients under 40 years of age]
• [Comparative study of human fetal and adult bone marrow derived mesenchymal stem cells]
• [Different serum lipid adjustment drugs for the treatment of hyperlipidemic fatty liver]
• [Effects of air pollution from burning coal on respiratory diseases in adults]
• [Expression of protooncogene c-jun, p38 and proliferating cell nuclear antigen in intestinal epithelial cells in rats different development stages]
• [Inhibition of human gastric carcinoma cell growth by vitamin E succinate]
• [Isolation and identification of chemical constituents from Albizia julibrissin Durazz.]
• [Peritoneal lavage cytology in 66 patients with gastric carcinoma]
• [Relationship between endotracheal intubation pattern and nosocomial infection of medical staff during treatment of severe acute respiratory syndrome]
• [Research on embryonic stem cells]
• [State of the art in the study of postburn ischemic/hypoxic injury]
• [Study of autofluorescence spectrum of dilute gastric juice in the diagnosis of gastric carcinoma]
• [Study on the chemical components of edible oil fume in kitchen and its genotoxity on Drosophila]
• [Study on vitamin E succinate inducing apoptosis of human gastric carcinoma cell]
• [Survey of taenia saginata infection in students in Harbin city]
• [The clinical staging and tissue bacterial quantification in the diagnosis of burn wound sepsis]
• [Ultrasonically guided radio-frequency ablation of liver tumors with a clustered electrode: a report of 100 cases]