Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.

Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Research Abstract Details 

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Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Abstract Text:

Marni Hall,Mary Gamble,Vesna Slavkovich,Xinhua Liu,Diane Levy,Zhongqi Cheng,Alexander van Geen,Mahammad Yunus,Mahfuzar Rahman,J Richard Pilsner,Joseph Graziano,

BACKGROUND: In Bangladesh, tens of millions of people have been consuming waterborne arsenic for decades. The extent to which As is transported to the fetus during pregnancy has not been well characterized. OBJECTIVES: We therefore conducted a study of 101 pregnant women who gave birth in Matlab, Bangladesh. METHODS: Maternal and cord blood pairs were collected and concentrations of total As were analyzed for 101 pairs, and As metabolites for 30 pairs. Maternal urinary As metabolites and plasma folate, cobalamin, and homocysteine levels in maternal cord pairs were also measured. Household tube well-water As concentrations exceeded the World Health Organization guideline of 10 microg/L in 38% of the cases. RESULTS: We observed strong associations between maternal and cord blood concentrations of total As (r = 0.93, p < 0.0001). Maternal and cord blood arsenic metabolites (n = 30) were also strongly correlated: in dimethylarsinate (DMA) (r = 0.94, p < 0.0001), monomethylarsonate (r = 0.80, p < 0.0001), arsenite (As(+3)) (r = 0.80, p < 0.0001), and arsenate (As(+5)) (r = 0.89, p < 0.0001). Maternal homocysteine was a strong predictor of %DMA in maternal urine, maternal blood, and cord blood (beta = -6.2, p < 0.02; beta = -10.9, p < 0.04; and beta = -13.7, p < 0.04, respectively). Maternal folate was inversely associated with maternal blood As(5+) (beta = 0.56, p < 0.05), and maternal cobalamin was inversely associated with cord blood As(5+) (beta = -1.2, p < 0.01). CONCLUSIONS: We conclude that exposure to all metabolites of inorganic As occurs in the prenatal period.

Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Publishing Authors By Initials

M Hall,M Gamble,V Slavkovich,X Liu,D Levy,Z Cheng,A van Geen,M Yunus,M Rahman,JR Pilsner,J Graziano,

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Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Environmental health perspectives

VOLUME: 115

Page Numbers: 1503-9

Journal Abbreviation: Environ. Health Perspect.

ISSN: 0091-6765

DAY: 16

MONTH: Oct

YEAR: 2007

Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs. Information

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LANGUAGE: eng

NlmUniqueID: 330411

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Grant and Affiliation Information for Determinants of arsenic metabolism: blood arsenic metabolites, plasma folate, cobalamin, and homocysteine concentrations in maternal-newborn pairs.

AFFILIATION: Department of Environmental Health Sciences, Columbia University Medical Center, New York, New York 10032, USA.

Country: United States

AGENCY: United States PHS

GRANT: R01 ESO11601

ACRONYM: ES

MEDLINETA: Environ Health Perspect

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