Detection of viral agents in fecal specimens of monkeys with diarrhea.

Detection of viral agents in fecal specimens of monkeys with diarrhea. Research Abstract Details 

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Detection of viral agents in fecal specimens of monkeys with diarrhea. Abstract Text:

Yuhuan Wang,Xinming Tu,Charles Humphrey,Harold McClure,Xi Jiang,Chuan Qin,Roger I Glass,Baoming Jiang,

BACKGROUND: Diarrheal disease is a major cause of morbidity and mortality in humans and animals, including non human primates. While the diagnostics for gastrointestinal bacterial and parasitic pathogens and their etiological role in disease are well established, little is known about the epidemiology, prevalence and role of viral agents in diarrheal illness among monkeys. METHODS: We collected fecal specimens from monkeys with diarrhea that were housed in two primate colonies, the Institute of Laboratory Animal Sciences, Beijing, China and the Yerkes National Primate Research Center, Georgia, USA. We screened these fecal specimens for rotaviruses and enteric adenoviruses 40/41 by using commercial EIA kits (Rotaclone and Adenoclone), enteroviruses by RT-PCR and Southern blot hybridization, and picobirnaviruses by polyacrylamide gel electrophoresis and silver staining. Some of the specimens were examined by EM for coronaviruses and noroviruses. RESULTS: Of the 92 specimens from China, we found 63 (68%) positive for viruses, including enteroviruses (52%), enteric adenoviruses (21%), rotaviruses (20%), and picobirnaviruses (2%). Coronaviruses were detected in some specimens. Mixed infection of two or more viral agents was seen in 23 (25%) specimens. In the US collection, we detected enteroviruses and enteric adenoviruses in 76% (45/59) and 14% (7/50) of the specimens, respectively. Electron microscopy showed norovirus-like particles in some specimens from both colonies. CONCLUSIONS: Our findings indicate endemic infections with enteric viruses in monkeys of both colonies. The availability of new simian rotaviruses, enteric adenoviruses, enteroviruses, and coronaviruses and the discovery of noroviruses and picobirnaviruses may allow us to develop better diagnostics for these agents and determine which of these agents are clearly associated with gastroenteritis in monkeys.

Detection of viral agents in fecal specimens of monkeys with diarrhea. Publishing Authors By Initials

Y Wang,X Tu,C Humphrey,H McClure,X Jiang,C Qin,RI Glass,B Jiang,

For similar virus diseases research abstracts see: virus diseases research

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Detection of viral agents in fecal specimens of monkeys with diarrhea. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medical primatology

VOLUME: 36

Page Numbers: 101-7

Journal Abbreviation: J. Med. Primatol.

ISSN: 0047-2565

DAY: 3

MONTH: Apr

YEAR: 2007

Detection of viral agents in fecal specimens of monkeys with diarrhea. Information

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LANGUAGE: eng

NlmUniqueID: 320626

Detection of viral agents in fecal specimens of monkeys with diarrhea. Keywords Mesh Terms:

KEYWORDS: Virus Diseases

MESH TERMS: veterinary

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Grant and Affiliation Information for Detection of viral agents in fecal specimens of monkeys with diarrhea.

AFFILIATION: Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Emory University, Atlanta, GA, USA.

Country: Denmark

AGENCY: United States NCRR

GRANT: RR00165

ACRONYM: RR

MEDLINETA: J Med Primatol

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