Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging.

Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Research Abstract Details 

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Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Abstract Text:

A Rahmouni,M Divine,D Mathieu,M Golli,T H Dao,N Jazaerli,M C Anglade,F Reyes,N Vasile,

OBJECTIVE. To determine the efficacy of fat-suppressed sequences and contrast-enhanced MR imaging for the detection of focal spinal lesions caused by multiple myeloma, we obtained MR images in 32 patients with newly diagnosed myeloma who had back pain. SUBJECTS AND METHODS. All patients had biopsy-proved myeloma and had MR imaging at the painful level of the spine. Spin-echo T1-weighted, T2-weighted, and short TI inversion-recovery (STIR) images; dynamic ultrafast low-angle shot (turbo-FLASH) images after IV injection of a bolus of paramagnetic contrast material; and contrast-enhanced T1-weighted images were obtained. We qualitatively compared the signal intensities and contrast enhancement of focal lesions with those of the surrounding vertebral bodies. RESULTS. Multiple lesions were detected in all but two of the 32 patients. On T2-weighted and STIR images, all lesions had homogeneously high signal intensity. On T1-weighted images, the lesions were visible as hypointense areas compared with surrounding bone in all except four patients, in whom the lesions were isointense or hyperintense. All tumor nodules enhanced on turbo-FLASH images obtained in the arterial phase. No additional lesions were seen on STIR or contrast-enhanced images. MR findings resulted in a change in the staging of the disease in one patient and led to prompt treatment in five patients with epidural involvement. CONCLUSION. MR imaging appears to be helpful in detecting spinal involvement in patients with multiple myeloma. The diagnosis of spinal lesions is best achieved by using either fat-suppressed or T2-weighted images. Although myeloma lesions enhanced in all patients, contrast material appears to be of no value for the detection of additional lesions.

Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Publishing Authors By Initials

A Rahmouni,M Divine,D Mathieu,M Golli,TH Dao,N Jazaerli,MC Anglade,F Reyes,N Vasile,

For similar musculoskeletal system: skeleton: bone and bones: spine research abstracts see: musculoskeletal system: skeleton: bone and bones: spine research

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Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: AJR. American journal of roentgenology

VOLUME: 160

Page Numbers: 1049-52

Journal Abbreviation:

ISSN: 0361-803X

DAY: 15

MONTH: May

YEAR: 1993

Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Information

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LANGUAGE: eng

NlmUniqueID: 7708173

Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Keywords Mesh Terms:

KEYWORDS: Spine

MESH TERMS: pathology

Chemical & Substance for Abstract: Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging. Information

Substance Name: gadolinium 1,4,7,10-tetraazacyclododecan

Registry Number: 92923-44-9

Grant and Affiliation Information for Detection of multiple myeloma involving the spine: efficacy of fat-suppression and contrast-enhanced MR imaging.

AFFILIATION: Department of Radiology, Hôpital Henri Mondor, Créteil, France.

Country: UNITED STATES

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MEDLINETA: AJR Am J Roentgenol

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