Detection of interactions between nucleosome arrays mediated by specific core histone tail domains.

Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Research Abstract Details 

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Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Abstract Text:

Pu-Yeh Kan,Jeffrey J Hayes,

The core histone tail domains play important roles in different stages of chromatin condensation. The tails are required for folding nucleosome arrays into secondary chromatin structures such as the approximately 30 nm diameter chromatin fiber and for mediating fiber-fiber interactions important for formation of tertiary chromatin structures. Crosslinking studies have demonstrated that inter-nucleosomal tail-DNA contacts appear in conjunction with salt-induced folding of nucleosome arrays into in higher order chromatin structures. However, since both folding of nucleosome arrays and fiber-fiber interactions take place simultaneously in >2-3 mM MgCl(2) such inter-nucleosome interactions may reflect short range (intra-array) or longer range (inter-array) interactions. Here, we describe a novel technique to specifically identify inter-array interactions mediated by the histone tail domains. In addition, we describe a new method for the preparation of H3/H4 tetramers.

Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Publishing Authors By Initials

PY Kan,JJ Hayes,

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Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Methods (San Diego, Calif.)

VOLUME: 41

Page Numbers: 278-85

Journal Abbreviation: Methods

ISSN: 1046-2023

DAY: 3

MONTH: Mar

YEAR: 2007

Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Information

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LANGUAGE: eng

NlmUniqueID: 9426302

Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Keywords Mesh Terms:

KEYWORDS: Tritium

MESH TERMS: chemistry

Chemical & Substance for Abstract: Detection of interactions between nucleosome arrays mediated by specific core histone tail domains. Information

Substance Name: Tritium

Registry Number: 10028-17-8

Grant and Affiliation Information for Detection of interactions between nucleosome arrays mediated by specific core histone tail domains.

AFFILIATION: Department of Biochemistry and Biophysics, Box 712, University of Rochester Medical Center, Rochester, NY 14642, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM52426

ACRONYM: GM

MEDLINETA: Methods

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